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Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Shi Y, et al. Among authors: luo z. Mol Cell. 2022 May 5;82(9):1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007. Epub 2022 Mar 24. Mol Cell. 2022. PMID: 35334231 Free PMC article.
Structure and Metal Binding Properties of Chlamydia trachomatis YtgA.
Luo Z, Neville SL, Campbell R, Morey JR, Menon S, Thomas M, Eijkelkamp BA, Ween MP, Huston WM, Kobe B, McDevitt CA. Luo Z, et al. J Bacteriol. 2019 Dec 6;202(1):e00580-19. doi: 10.1128/JB.00580-19. Print 2019 Dec 6. J Bacteriol. 2019. PMID: 31611288 Free PMC article.
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Among authors: luo z. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.
Struwe MA, Kalimuthu P, Luo Z, Zhong Q, Ellis D, Yang J, Khadanand KC, Harmer JR, Kirk ML, McEwan AG, Clement B, Bernhardt PV, Kobe B, Kappler U. Struwe MA, et al. Among authors: luo z. J Biol Chem. 2021 Jan-Jun;296:100672. doi: 10.1016/j.jbc.2021.100672. Epub 2021 Apr 20. J Biol Chem. 2021. PMID: 33887324 Free PMC article.
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