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8,015 results

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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L. Wang C, et al. Among authors: luo w. Nat Commun. 2022 Apr 12;13(1):1969. doi: 10.1038/s41467-022-29552-6. Nat Commun. 2022. PMID: 35413950 Free PMC article.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C; Alzheimer’s Disease Neuroimaging Initiative; Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM. Shi Y, et al. Among authors: luo w. Nature. 2017 Sep 28;549(7673):523-527. doi: 10.1038/nature24016. Epub 2017 Sep 20. Nature. 2017. PMID: 28959956 Free PMC article.
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, Che AY, Taldone T, Yan P, Sun W, Uddin M, Panchal P, Riolo M, Shah S, Barlas A, Xu K, Chan LYL, Gruzinova A, Kishinevsky S, Studer L, Fossati V, Noggle SA, White JR, de Stanchina E, Sequeira S, Anthoney KH, Steele JW, Manova-Todorova K, Patil S, Dunphy MP, Pillarsetty N, Pereira AC, Erdjument-Bromage H, Neubert TA, Rodina A, Ginsberg SD, De Marco Garcia N, Luo W, Chiosis G. Inda MC, et al. Among authors: luo w. Nat Commun. 2020 Jan 16;11(1):319. doi: 10.1038/s41467-019-14082-5. Nat Commun. 2020. PMID: 31949159 Free PMC article.
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. Sayed FA, et al. Among authors: luo w. Sci Transl Med. 2021 Dec;13(622):eabe3947. doi: 10.1126/scitranslmed.abe3947. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851693 Free PMC article.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. Tracy TE, et al. Among authors: luo w. Cell. 2022 Feb 17;185(4):712-728.e14. doi: 10.1016/j.cell.2021.12.041. Epub 2022 Jan 20. Cell. 2022. PMID: 35063084 Free PMC article.
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.
Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MM, Koopmans F, Prjibelski AD, Mikheenko A, Belchikov N, Jarroux J, Lucas AB, Palkovits M, Luo W, Milner TA, Ndhlovu LC, Smit AB, Trojanowski JQ, Lee VMY, Fedrigo O, Sloan SA, Tombácz D, Ross ME, Jarvis E, Boldogkői Z, Gan L, Tilgner HU. Hardwick SA, et al. Among authors: luo w. Nat Biotechnol. 2022 Jul;40(7):1082-1092. doi: 10.1038/s41587-022-01231-3. Epub 2022 Mar 7. Nat Biotechnol. 2022. PMID: 35256815 Free PMC article.
Friend turned foe: TREM2 agonist in battles against tau.
Carling G, Luo W, Gan L. Carling G, et al. Among authors: luo w. J Exp Med. 2023 Jan 2;220(1):e20221850. doi: 10.1084/jem.20221850. Epub 2022 Nov 18. J Exp Med. 2023. PMID: 36399126 Free PMC article.
8,015 results