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HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
Li L, Kim JH, Lu W, Williams DM, Kim J, Cope L, Rampal RK, Koche RP, Xian L, Luo LZ, Vasiljevic M, Matson DR, Zhao ZJ, Rogers O, Stubbs MC, Reddy K, Romero AR, Psaila B, Spivak JL, Moliterno AR, Resar LMS. Li L, et al. Among authors: luo lz. Blood. 2022 May 5;139(18):2797-2815. doi: 10.1182/blood.2021013925. Blood. 2022. PMID: 35286385 Free PMC article.
STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway.
Belton A, Xian L, Huso T, Koo M, Luo LZ, Turkson J, Page BD, Gunning PT, Liu G, Huso DL, Resar LM. Belton A, et al. Among authors: luo lz. Leuk Lymphoma. 2016 Nov;57(11):2681-4. doi: 10.3109/10428194.2016.1153089. Epub 2016 Mar 8. Leuk Lymphoma. 2016. PMID: 26952843 Free PMC article. No abstract available.
The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.
Hillion J, Roy S, Heydarian M, Cope L, Xian L, Koo M, Luo LZ, Kellyn K, Ronnett BM, Huso T, Armstrong D, Reddy K, Huso DL, Resar LMS. Hillion J, et al. Among authors: luo lz. Gynecol Oncol. 2016 Jun;141(3):580-587. doi: 10.1016/j.ygyno.2016.03.020. Epub 2016 Apr 8. Gynecol Oncol. 2016. PMID: 27001612 Free PMC article.
HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation.
Chia L, Wang B, Kim JH, Luo LZ, Shuai S, Herrera I, Chen SY, Li L, Xian L, Huso T, Heydarian M, Reddy K, Sung WJ, Ishiyama S, Guo G, Jaffee E, Zheng L, Cope LM, Gabrielson K, Wood L, Resar L. Chia L, et al. Among authors: luo lz. J Clin Invest. 2023 Mar 15;133(6):e151601. doi: 10.1172/JCI151601. J Clin Invest. 2023. PMID: 36919699 Free PMC article.
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism.
Wang G, Sweren E, Andrews W, Li Y, Chen J, Xue Y, Wier E, Alphonse MP, Luo L, Miao Y, Chen R, Zeng D, Lee S, Li A, Dare E, Kim D, Archer NK, Reddy SK, Resar L, Hu Z, Grice EA, Kane MA, Garza LA. Wang G, et al. Sci Adv. 2023 Jan 4;9(1):eabo7555. doi: 10.1126/sciadv.abo7555. Epub 2023 Jan 4. Sci Adv. 2023. PMID: 36598999 Free PMC article.
87 results