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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Słabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thomä NH, Ebert BL. Tsai JM, et al. Among authors: lumpkin rj. Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. doi: 10.1016/j.molcel.2023.06.028. Epub 2023 Jul 20. Mol Cell. 2023. PMID: 37478846 Free article.
Targeted Degradation of the Oncogenic Phosphatase SHP2.
Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Vemulapalli V, et al. Among authors: lumpkin rj. Biochemistry. 2021 Aug 31;60(34):2593-2609. doi: 10.1021/acs.biochem.1c00377. Epub 2021 Aug 19. Biochemistry. 2021. PMID: 34411482 Free PMC article.
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Lumpkin R, Sandoval B, Jin CY, Ficarro SB, Wang MY, Xu S, Groendyke BJ, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Li YD, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528208. doi: 10.1101/2023.02.14.528208. bioRxiv. 2023. PMID: 36824856 Free PMC article. Preprint.
Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. bioRxiv [Preprint]. 2023 Oct 10:2023.10.07.561308. doi: 10.1101/2023.10.07.561308. bioRxiv. 2023. PMID: 37873358 Free PMC article. Preprint.
Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. Lumpkin RJ, et al. Nat Commun. 2020 Jun 8;11(1):2866. doi: 10.1038/s41467-020-16499-9. Nat Commun. 2020. PMID: 32513959 Free PMC article.
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. Lumpkin RJ, et al. Mol Cell Proteomics. 2021;20:100019. doi: 10.1074/mcp.RA120.002414. Epub 2021 Jan 6. Mol Cell Proteomics. 2021. PMID: 33268465 Free PMC article.
15 results