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Page 1
Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity.
Régnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, Lippi Y, Fouché E, Lasserre F, Naylies C, Bétoulières C, Barquissau V, Mouisel E, Bertrand-Michel J, Batut A, Saati TA, Canlet C, Tremblay-Franco M, Ellero-Simatos S, Langin D, Postic C, Wahli W, Loiseau N, Guillou H, Montagner A. Régnier M, et al. Among authors: lukowicz c. Sci Rep. 2020 Apr 16;10(1):6489. doi: 10.1038/s41598-020-63579-3. Sci Rep. 2020. PMID: 32300166 Free PMC article.
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.
Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Montagner A, et al. Among authors: lukowicz c. Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1. Gut. 2016. PMID: 26838599 Free PMC article.
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L. Marmugi A, et al. Among authors: lukowicz c. Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11. Toxicol Appl Pharmacol. 2016. PMID: 27180240
Insights into the role of hepatocyte PPARα activity in response to fasting.
Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, Smati S, Marrot A, Lasserre F, Naylies C, Batut A, Viars F, Bertrand-Michel J, Postic C, Loiseau N, Wahli W, Guillou H, Montagner A. Régnier M, et al. Among authors: lukowicz c. Mol Cell Endocrinol. 2018 Aug 15;471:75-88. doi: 10.1016/j.mce.2017.07.035. Epub 2017 Jul 31. Mol Cell Endocrinol. 2018. PMID: 28774777
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.
Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C. Iroz A, et al. Among authors: lukowicz c. Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065. Cell Rep. 2017. PMID: 29020627 Free PMC article.
Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor.
Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A, Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L. Lukowicz C, et al. Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877. eCollection 2018 Jun. Environ Health Perspect. 2018. PMID: 29950287 Free PMC article.
The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity.
Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N. Régnier M, et al. Among authors: lukowicz c. Arch Toxicol. 2019 Feb;93(2):505-517. doi: 10.1007/s00204-018-2345-2. Epub 2018 Nov 17. Arch Toxicol. 2019. PMID: 30448865 Free article.
Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes.
Smati S, Régnier M, Fougeray T, Polizzi A, Fougerat A, Lasserre F, Lukowicz C, Tramunt B, Guillaume M, Burnol AF, Postic C, Wahli W, Montagner A, Gourdy P, Guillou H. Smati S, et al. Among authors: lukowicz c. Diabetes Metab. 2020 Apr;46(2):129-136. doi: 10.1016/j.diabet.2019.05.005. Epub 2019 Jun 1. Diabetes Metab. 2020. PMID: 31163275
Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice.
Barretto SA, Lasserre F, Fougerat A, Smith L, Fougeray T, Lukowicz C, Polizzi A, Smati S, Régnier M, Naylies C, Bétoulières C, Lippi Y, Guillou H, Loiseau N, Gamet-Payrastre L, Mselli-Lakhal L, Ellero-Simatos S. Barretto SA, et al. Among authors: lukowicz c. Int J Mol Sci. 2019 Aug 1;20(15):3767. doi: 10.3390/ijms20153767. Int J Mol Sci. 2019. PMID: 31374856 Free PMC article.
Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor.
Lukowicz C, Ellero-Simatos S, Régnier M, Oliviero F, Lasserre F, Polizzi A, Montagner A, Smati S, Boudou F, Lenfant F, Guzylack-Pirou L, Menard S, Barretto S, Fougerat A, Lippi Y, Naylies C, Bertrand-Michel J, Belgnaoui AA, Theodorou V, Marchi N, Gourdy P, Gamet-Payrastre L, Loiseau N, Guillou H, Mselli-Lakhal L. Lukowicz C, et al. Sci Rep. 2019 Dec 27;9(1):20169. doi: 10.1038/s41598-019-56570-0. Sci Rep. 2019. PMID: 31882815 Free PMC article.
16 results