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Mutation-specific downregulation of CFTR2 variants by gating potentiators.
Avramescu RG, Kai Y, Xu H, Bidaud-Meynard A, Schnúr A, Frenkiel S, Matouk E, Veit G, Lukacs GL. Avramescu RG, et al. Among authors: lukacs gl. Hum Mol Genet. 2017 Dec 15;26(24):4873-4885. doi: 10.1093/hmg/ddx367. Hum Mol Genet. 2017. PMID: 29040544 Free PMC article.
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
Colas J, Faure G, Saussereau E, Trudel S, Rabeh WM, Bitam S, Guerrera IC, Fritsch J, Sermet-Gaudelus I, Davezac N, Brouillard F, Lukacs GL, Herrmann H, Ollero M, Edelman A. Colas J, et al. Among authors: lukacs gl. Hum Mol Genet. 2012 Feb 1;21(3):623-34. doi: 10.1093/hmg/ddr496. Epub 2011 Oct 28. Hum Mol Genet. 2012. PMID: 22038833 Free PMC article.
Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL. Okiyoneda T, et al. Among authors: lukacs gl. Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12. Nat Chem Biol. 2013. PMID: 23666117 Free PMC article.
167 results