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Structure-Guided Design of Antibodies.
Caravella JA, Wang D, Glaser SM, Lugovskoy A. Caravella JA, et al. Among authors: lugovskoy a. Curr Comput Aided Drug Des. 2010;6(2):128-38. Curr Comput Aided Drug Des. 2010. PMID: 26845329 Review.
Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR.
Michaelson JS, Demarest SJ, Miller B, Amatucci A, Snyder WB, Wu X, Huang F, Phan S, Gao S, Doern A, Farrington GK, Lugovskoy A, Joseph I, Bailly V, Wang X, Garber E, Browning J, Glaser SM. Michaelson JS, et al. Among authors: lugovskoy a. MAbs. 2009 Mar-Apr;1(2):128-41. doi: 10.4161/mabs.1.2.7631. Epub 2009 Mar 11. MAbs. 2009. PMID: 20061822 Free PMC article.
Structure-Guided Design of Antibodies.
Caravella JA, Wang D, Glaser SM, Lugovskoy A. Caravella JA, et al. Among authors: lugovskoy a. Curr Comput Aided Drug Des. 2010 Apr 6. Online ahead of print. Curr Comput Aided Drug Des. 2010. PMID: 20402665
Design of next-generation protein therapeutics.
Caravella J, Lugovskoy A. Caravella J, et al. Among authors: lugovskoy a. Curr Opin Chem Biol. 2010 Aug;14(4):520-8. doi: 10.1016/j.cbpa.2010.06.175. Epub 2010 Jul 16. Curr Opin Chem Biol. 2010. PMID: 20638324 Review.
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong J, Sereno A, Snyder WB, Miller BR, Tamraz S, Doern A, Favis M, Wu X, Tran H, Langley E, Joseph I, Boccia A, Kelly R, Wortham K, Wang Q, Berquist L, Huang F, Gao SX, Zhang Y, Lugovskoy A, Martin S, Gouvis H, Berkowitz S, Chiang G, Reff M, Glaser SM, Hariharan K, Demarest SJ. Dong J, et al. Among authors: lugovskoy a. J Biol Chem. 2011 Feb 11;286(6):4703-17. doi: 10.1074/jbc.M110.184317. Epub 2010 Dec 1. J Biol Chem. 2011. PMID: 21123183 Free PMC article.
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Marcotte D, Zeng W, Hus JC, McKenzie A, Hession C, Jin P, Bergeron C, Lugovskoy A, Enyedy I, Cuervo H, Wang D, Atmanene C, Roecklin D, Vecchi M, Vivat V, Kraemer J, Winkler D, Hong V, Chao J, Lukashev M, Silvian L. Marcotte D, et al. Among authors: lugovskoy a. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9. doi: 10.1016/j.bmc.2013.04.019. Epub 2013 Apr 19. Bioorg Med Chem. 2013. PMID: 23647822
59 results