Luesch H - Search Results

1

A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.

Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, Huigens RW 3rd. Yang H, et al. Among authors: luesch h. J Med Chem. 2021 Jun 10;64(11):7275-7295. doi: 10.1021/acs.jmedchem.1c00168. Epub 2021 Apr 21. J Med Chem. 2021. PMID: 33881312 Free PMC article.

2

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.

Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. Kwan JC, et al. Among authors: luesch h. J Med Chem. 2009 Sep 24;52(18):5732-47. doi: 10.1021/jm9009394. J Med Chem. 2009. PMID: 19715320 Free PMC article.

3

Marine natural products: a new wave of drugs?

Montaser R, Luesch H. Montaser R, et al. Among authors: luesch h. Future Med Chem. 2011 Sep;3(12):1475-89. doi: 10.4155/fmc.11.118. Future Med Chem. 2011. PMID: 21882941 Free PMC article.

4

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.

Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Liu Y, et al. Among authors: luesch h. J Med Chem. 2012 Dec 13;55(23):10749-65. doi: 10.1021/jm301630s. Epub 2012 Nov 26. J Med Chem. 2012. PMID: 23181502

5

Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.

Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H. Salvador LA, et al. Among authors: luesch h. J Med Chem. 2013 Feb 14;56(3):1276-90. doi: 10.1021/jm3017305. Epub 2013 Jan 28. J Med Chem. 2013. PMID: 23350733 Free PMC article.

6

Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity.

Chen QY, Liu Y, Cai W, Luesch H. Chen QY, et al. Among authors: luesch h. J Med Chem. 2014 Apr 10;57(7):3011-29. doi: 10.1021/jm4019965. Epub 2014 Mar 24. J Med Chem. 2014. PMID: 24660812 Free PMC article.

7

Evaluation of class I HDAC isoform selectivity of largazole analogues.

Kim B, Park H, Salvador LA, Serrano PE, Kwan JC, Zeller SL, Chen QY, Ryu S, Liu Y, Byeon S, Luesch H, Hong J. Kim B, et al. Among authors: luesch h. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3728-31. doi: 10.1016/j.bmcl.2014.07.006. Epub 2014 Jul 9. Bioorg Med Chem Lett. 2014. PMID: 25070421 Free PMC article.

8

Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis.

Garrison AT, Abouelhassan Y, Kallifidas D, Bai F, Ukhanova M, Mai V, Jin S, Luesch H, Huigens RW 3rd. Garrison AT, et al. Among authors: luesch h. Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14819-23. doi: 10.1002/anie.201508155. Epub 2015 Oct 20. Angew Chem Int Ed Engl. 2015. PMID: 26480852

9

Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.

Garrison AT, Abouelhassan Y, Norwood VM 4th, Kallifidas D, Bai F, Nguyen MT, Rolfe M, Burch GM, Jin S, Luesch H, Huigens RW 3rd. Garrison AT, et al. Among authors: luesch h. J Med Chem. 2016 Apr 28;59(8):3808-25. doi: 10.1021/acs.jmedchem.5b02004. Epub 2016 Apr 6. J Med Chem. 2016. PMID: 27018907

10

A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.

Paciaroni NG, Ratnayake R, Matthews JH, Norwood VM 4th, Arnold AC, Dang LH, Luesch H, Huigens RW 3rd. Paciaroni NG, et al. Among authors: luesch h. Chemistry. 2017 Mar 28;23(18):4327-4335. doi: 10.1002/chem.201604795. Epub 2017 Feb 3. Chemistry. 2017. PMID: 27900785 Free PMC article.

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