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The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Düsterhöft S, Kahveci-Türköz S, Wozniak J, Seifert A, Kasparek P, Ohm H, Liu S, Kopkanova J, Lokau J, Garbers C, Preisinger C, Sedlacek R, Freeman M, Ludwig A. Düsterhöft S, et al. Among authors: ludwig a. Cell Mol Life Sci. 2021 Jun;78(11):5015-5040. doi: 10.1007/s00018-021-03845-3. Epub 2021 May 5. Cell Mol Life Sci. 2021. PMID: 33950315 Free PMC article.
Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1.
Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, Sechi AS, Uhlig S, Ludwig A. Schwarz N, et al. Among authors: ludwig a. Cell Mol Life Sci. 2010 Dec;67(24):4233-48. doi: 10.1007/s00018-010-0433-4. Epub 2010 Jun 18. Cell Mol Life Sci. 2010. PMID: 20559678
A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation.
Pasqualon T, Pruessmeyer J, Weidenfeld S, Babendreyer A, Groth E, Schumacher J, Schwarz N, Denecke B, Jahr H, Zimmermann P, Dreymueller D, Ludwig A. Pasqualon T, et al. Among authors: ludwig a. Cell Mol Life Sci. 2015 Oct;72(19):3783-801. doi: 10.1007/s00018-015-1912-4. Epub 2015 Apr 26. Cell Mol Life Sci. 2015. PMID: 25912030
The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion.
Koenen A, Babendreyer A, Schumacher J, Pasqualon T, Schwarz N, Seifert A, Deupi X, Ludwig A, Dreymueller D. Koenen A, et al. Among authors: ludwig a. PLoS One. 2017 Mar 7;12(3):e0173486. doi: 10.1371/journal.pone.0173486. eCollection 2017. PLoS One. 2017. PMID: 28267793 Free PMC article.
Status update on iRhom and ADAM17: It's still complicated.
Düsterhöft S, Babendreyer A, Giese AA, Flasshove C, Ludwig A. Düsterhöft S, et al. Among authors: ludwig a. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1567-1583. doi: 10.1016/j.bbamcr.2019.06.017. Epub 2019 Jul 19. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31330158 Free article. Review.
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Seifert A, Düsterhöft S, Wozniak J, Koo CZ, Tomlinson MG, Nuti E, Rossello A, Cuffaro D, Yildiz D, Ludwig A. Seifert A, et al. Among authors: ludwig a. Cell Mol Life Sci. 2021 Jan;78(2):715-732. doi: 10.1007/s00018-020-03507-w. Epub 2020 May 5. Cell Mol Life Sci. 2021. PMID: 32372373 Free PMC article.
1,284 results