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ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues.
Bayer H, Lang K, Buck E, Higelin J, Barteczko L, Pasquarelli N, Sprissler J, Lucas T, Holzmann K, Demestre M, Lindenberg KS, Danzer KM, Boeckers T, Ludolph AC, Dupuis L, Weydt P, Witting A. Bayer H, et al. Among authors: ludolph ac. Neurobiol Dis. 2017 Jan;97(Pt A):36-45. doi: 10.1016/j.nbd.2016.11.001. Epub 2016 Nov 3. Neurobiol Dis. 2017. PMID: 27818323
Superoxide dismutase 1 modulates expression of transferrin receptor.
Danzeisen R, Achsel T, Bederke U, Cozzolino M, Crosio C, Ferri A, Frenzel M, Gralla EB, Huber L, Ludolph A, Nencini M, Rotilio G, Valentine JS, Carrì MT. Danzeisen R, et al. J Biol Inorg Chem. 2006 Jun;11(4):489-98. doi: 10.1007/s00775-006-0099-4. Epub 2006 Apr 26. J Biol Inorg Chem. 2006. PMID: 16680451
MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS.
Fang L, Teuchert M, Huber-Abel F, Schattauer D, Hendrich C, Dorst J, Zettlmeissel H, Wlaschek M, Scharffetter-Kochanek K, Kapfer T, Tumani H, Ludolph AC, Brettschneider J. Fang L, et al. Among authors: ludolph ac. J Neurol Sci. 2010 Jul 15;294(1-2):51-6. doi: 10.1016/j.jns.2010.04.005. Epub 2010 May 4. J Neurol Sci. 2010. PMID: 20441996
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Braunstein KE, Eschbach J, Ròna-Vörös K, Soylu R, Mikrouli E, Larmet Y, René F, Gonzalez De Aguilar JL, Loeffler JP, Müller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstöcker B, Kassubek J, Pichler B, Stiller D, Petersen A, Ludolph AC, Dupuis L. Braunstein KE, et al. Among authors: ludolph ac. Hum Mol Genet. 2010 Nov 15;19(22):4385-98. doi: 10.1093/hmg/ddq361. Epub 2010 Aug 31. Hum Mol Genet. 2010. PMID: 20807776 Free PMC article.
Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.
Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M, Schwalenstocker B, Loeffler JP, Ludolph AC, Dupuis L. Eschbach J, et al. Among authors: ludolph ac. Biochim Biophys Acta. 2011 Jan;1812(1):59-69. doi: 10.1016/j.bbadis.2010.09.009. Epub 2010 Sep 29. Biochim Biophys Acta. 2011. PMID: 20887786 Free article.
Energy metabolism in amyotrophic lateral sclerosis.
Dupuis L, Pradat PF, Ludolph AC, Loeffler JP. Dupuis L, et al. Among authors: ludolph ac. Lancet Neurol. 2011 Jan;10(1):75-82. doi: 10.1016/S1474-4422(10)70224-6. Epub 2010 Oct 27. Lancet Neurol. 2011. PMID: 21035400 Review.
787 results