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Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.
Cells. 2019 Nov 12;8(11):1425. doi: 10.3390/cells8111425.
Cells. 2019.
PMID: 31726720
Free PMC article.
The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs).
Wiejak J, van Basten B, Luchowska-Stańska U, Hamilton G, Yarwood SJ.
Wiejak J, et al. Among authors: luchowska stanska u.
Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):264-276. doi: 10.1016/j.bbamcr.2018.11.004. Epub 2018 Nov 9.
Biochim Biophys Acta Mol Cell Res. 2019.
PMID: 30414891
Free PMC article.
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Selective small-molecule EPAC activators.
Luchowska-Stańska U, Morgan D, Yarwood SJ, Barker G.
Luchowska-Stańska U, et al.
Biochem Soc Trans. 2019 Oct 31;47(5):1415-1427. doi: 10.1042/BST20190254.
Biochem Soc Trans. 2019.
PMID: 31671184
Free PMC article.
Review.
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Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators.
Wang P, Luchowska-Stańska U, van Basten B, Chen H, Liu Z, Wiejak J, Whelan P, Morgan D, Lochhead E, Barker G, Rehmann H, Yarwood SJ, Zhou J.
Wang P, et al. Among authors: luchowska stanska u.
J Med Chem. 2020 May 28;63(10):5159-5184. doi: 10.1021/acs.jmedchem.9b02094. Epub 2020 May 11.
J Med Chem. 2020.
PMID: 32340447
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Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1.
Buist HK, Luchowska-Stańska U, van Basten B, Valli J, Smith BO, Baillie GS, Rickman C, Ricketts B, Davidson A, Hannam R, Sunderland J, Yarwood SJ.
Buist HK, et al. Among authors: luchowska stanska u.
Cells. 2021 Sep 3;10(9):2307. doi: 10.3390/cells10092307.
Cells. 2021.
PMID: 34571955
Free PMC article.
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Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs.
Wiejak J, Luchowska-Stańska U, Wang P, Zhou J, Maffia P, Morgan D, Barker G, Yarwood SJ.
Wiejak J, et al. Among authors: luchowska stanska u.
Sci Rep. 2022 Oct 5;12(1):16505. doi: 10.1038/s41598-022-20607-8.
Sci Rep. 2022.
PMID: 36198739
Free PMC article.
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Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.
Shao H, Mohamed H, Boulton S, Huang J, Wang P, Chen H, Zhou J, Luchowska-Stańska U, Jentsch NG, Armstrong AL, Magolan J, Yarwood S, Melacini G.
Shao H, et al. Among authors: luchowska stanska u.
J Med Chem. 2020 May 14;63(9):4762-4775. doi: 10.1021/acs.jmedchem.9b02151. Epub 2020 Apr 16.
J Med Chem. 2020.
PMID: 32297742
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