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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging.
Santos HDA, Zabala Gutiérrez I, Shen Y, Lifante J, Ximendes E, Laurenti M, Méndez-González D, Melle S, Calderón OG, López Cabarcos E, Fernández N, Chaves-Coira I, Lucena-Agell D, Monge L, Mackenzie MD, Marqués-Hueso J, Jones CMS, Jacinto C, Del Rosal B, Kar AK, Rubio-Retama J, Jaque D. Santos HDA, et al. Nat Commun. 2020 Jun 10;11(1):2933. doi: 10.1038/s41467-020-16333-2. Nat Commun. 2020. PMID: 32523065 Free PMC article.
Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
Tang Y, Rodríguez-Salarichs J, Zhao Y, Cai P, Estévez-Gallego J, Balaguer-Pérez F, Redondo Horcajo M, Lucena-Agell D, Barasoain I, Díaz JF, Fang WS. Tang Y, et al. Eur J Med Chem. 2017 Sep 8;137:488-503. doi: 10.1016/j.ejmech.2017.06.001. Epub 2017 Jun 3. Eur J Med Chem. 2017. PMID: 28624703
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S. Brindisi M, et al. Eur J Med Chem. 2019 Jan 15;162:290-320. doi: 10.1016/j.ejmech.2018.11.004. Epub 2018 Nov 3. Eur J Med Chem. 2019. PMID: 30448418
Structural model for differential cap maturation at growing microtubule ends.
Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, Lucena-Agell D, Kamma-Lorger C, Yagi T, Iwamoto H, Duchesne L, Barasoain I, Steinmetz MO, Chrétien D, Kamimura S, Díaz JF, Oliva MA. Estévez-Gallego J, et al. Elife. 2020 Mar 10;9:e50155. doi: 10.7554/eLife.50155. Elife. 2020. PMID: 32151315 Free PMC article.
N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity.
Keenan B, Finol-Urdaneta RK, Hope A, Bremner JB, Kavallaris M, Lucena-Agell D, Oliva MÁ, Díaz JF, Vine KL. Keenan B, et al. Cancer Cell Int. 2020 May 15;20:170. doi: 10.1186/s12935-020-01251-6. eCollection 2020. Cancer Cell Int. 2020. PMID: 32467666 Free PMC article.
Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells.
Peronne L, Denarier E, Rai A, Prudent R, Vernet A, Suzanne P, Ramirez-Rios S, Michallet S, Guidetti M, Vollaire J, Lucena-Agell D, Ribba AS, Josserand V, Coll JL, Dallemagne P, Díaz JF, Oliva MÁ, Sadoul K, Akhmanova A, Andrieux A, Lafanechère L. Peronne L, et al. Cancers (Basel). 2020 Aug 6;12(8):2196. doi: 10.3390/cancers12082196. Cancers (Basel). 2020. PMID: 32781579 Free PMC article.
30 results