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Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for antimalarial intervention deployment.
Njoroge H, Van't Hof A, Oruni A, Pipini D, Nagi SC, Lynd A, Lucas ER, Tomlinson S, Grau-Bove X, McDermott D, Wat'senga FT, Manzambi EZ, Agossa FR, Mokuba A, Irish S, Kabula B, Mbogo C, Bargul J, Paine MJI, Weetman D, Donnelly MJ. Njoroge H, et al. Among authors: lucas er. Mol Ecol. 2022 Aug;31(16):4307-4318. doi: 10.1111/mec.16591. Epub 2022 Jul 12. Mol Ecol. 2022. PMID: 35775282 Free PMC article.
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus.
Grau-Bové X, Lucas E, Pipini D, Rippon E, van 't Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski D, Donnelly MJ, Weetman D; Anopheles gambiae 1000 Genomes Consortium. Grau-Bové X, et al. PLoS Genet. 2021 Jan 21;17(1):e1009253. doi: 10.1371/journal.pgen.1009253. eCollection 2021 Jan. PLoS Genet. 2021. PMID: 33476334 Free PMC article.
Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii.
Ingham VA, Tennessen JA, Lucas ER, Elg S, Yates HC, Carson J, Guelbeogo WM, Sagnon N, Hughes GL, Heinz E, Neafsey DE, Ranson H. Ingham VA, et al. Among authors: lucas er. PLoS Genet. 2021 Dec 23;17(12):e1009970. doi: 10.1371/journal.pgen.1009970. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34941884 Free PMC article.
Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae s.l.
Lucas ER, Nagi SC, Egyir-Yawson A, Essandoh J, Dadzie S, Chabi J, Djogbénou LS, Medjigbodo AA, Edi CV, Ketoh GK, Koudou BG, Van't Hof AE, Rippon EJ, Pipini D, Harding NJ, Dyer NA, Cerdeira LT, Clarkson CS, Kwiatkowski DP, Miles A, Donnelly MJ, Weetman D. Lucas ER, et al. bioRxiv [Preprint]. 2023 Jan 14:2023.01.13.523889. doi: 10.1101/2023.01.13.523889. bioRxiv. 2023. PMID: 36712022 Free PMC article. Updated. Preprint.
32 results