Luc Roumen - Search Results

Year	Number of Results
2007	3
2008	1
2010	1
2011	4
2012	4
2013	3
2014	1
2024	0

1

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.

Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R. Scholten DJ, et al. Among authors: roumen l. Mol Pharmacol. 2014 Jan;85(1):116-26. doi: 10.1124/mol.113.088633. Epub 2013 Oct 30. Mol Pharmacol. 2014. PMID: 24174496

2

From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands.

Kooistra AJ, Roumen L, Leurs R, de Esch IJ, de Graaf C. Kooistra AJ, et al. Among authors: roumen l. Methods Enzymol. 2013;522:279-336. doi: 10.1016/B978-0-12-407865-9.00015-7. Methods Enzymol. 2013. PMID: 23374191 Review.

3

Combining quantum mechanical ligand conformation analysis and protein modeling to elucidate GPCR-ligand binding modes.

Schultes S, Engelhardt H, Roumen L, Zuiderveld OP, Haaksma EE, de Esch IJ, Leurs R, de Graaf C. Schultes S, et al. Among authors: roumen l. ChemMedChem. 2013 Jan;8(1):49-53. doi: 10.1002/cmdc.201200412. Epub 2012 Nov 19. ChemMedChem. 2013. PMID: 23161844

4

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.

Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Wijtmans M, et al. Among authors: roumen l. J Med Chem. 2012 Dec 13;55(23):10572-83. doi: 10.1021/jm301240t. Epub 2012 Nov 14. J Med Chem. 2012. PMID: 23150943

5

Regiochemistry of the condensation of 2-aroyl-cyclohexanones and 2-cyanoacetamide: 13C-labeling studies and semiempirical MO calculations.

van Linden OP, Wijtmans M, Roumen L, Rotteveel L, Leurs R, de Esch IJ. van Linden OP, et al. Among authors: roumen l. J Org Chem. 2012 Sep 7;77(17):7355-63. doi: 10.1021/jo301138w. Epub 2012 Aug 16. J Org Chem. 2012. PMID: 22897640

6

A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design.

Sanders MP, Roumen L, van der Horst E, Lane JR, Vischer HF, van Offenbeek J, de Vries H, Verhoeven S, Chow KY, Verkaar F, Beukers MW, McGuire R, Leurs R, Ijzerman AP, de Vlieg J, de Esch IJ, Zaman GJ, Klomp JP, Bender A, de Graaf C. Sanders MP, et al. Among authors: roumen l. J Med Chem. 2012 Jun 14;55(11):5311-25. doi: 10.1021/jm300280e. Epub 2012 May 23. J Med Chem. 2012. PMID: 22563707

7

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Istyastono EP, Nijmeijer S, Lim HD, van de Stolpe A, Roumen L, Kooistra AJ, Vischer HF, de Esch IJ, Leurs R, de Graaf C. Istyastono EP, et al. Among authors: roumen l. J Med Chem. 2011 Dec 8;54(23):8136-47. doi: 10.1021/jm201042n. Epub 2011 Nov 7. J Med Chem. 2011. PMID: 22003888

8

Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.

de Kruijf P, Lim HD, Roumen L, Renjaän VA, Zhao J, Webb ML, Auld DS, Wijkmans JC, Zaman GJ, Smit MJ, de Graaf C, Leurs R. de Kruijf P, et al. Among authors: roumen l. Mol Pharmacol. 2011 Dec;80(6):1108-18. doi: 10.1124/mol.111.073825. Epub 2011 Sep 23. Mol Pharmacol. 2011. PMID: 21948388

9

Snooker: a structure-based pharmacophore generation tool applied to class A GPCRs.

Sanders MP, Verhoeven S, de Graaf C, Roumen L, Vroling B, Nabuurs SB, de Vlieg J, Klomp JP. Sanders MP, et al. Among authors: roumen l. J Chem Inf Model. 2011 Sep 26;51(9):2277-92. doi: 10.1021/ci200088d. Epub 2011 Sep 6. J Chem Inf Model. 2011. PMID: 21866955

10

Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.

Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ. Roumen L, et al. J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19. J Comput Chem. 2011. PMID: 21598279

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