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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Matthews JM, Qin N, Colburn RW, Dax SL, Hawkins M, McNally JJ, Reany L, Youngman MA, Baker J, Hutchinson T, Liu Y, Lubin ML, Neeper M, Brandt MR, Stone DJ, Flores CM. Matthews JM, et al. Among authors: lubin ml. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2922-6. doi: 10.1016/j.bmcl.2012.02.060. Epub 2012 Feb 27. Bioorg Med Chem Lett. 2012. PMID: 22421018
A novel series of pyrazolylpiperidine N-type calcium channel blockers.
Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Subasinghe NL, et al. Among authors: lubin ml. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2. Bioorg Med Chem Lett. 2012. PMID: 22608964
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.
Wall MJ, Subasinghe NL, Winters MP, Lubin ML, Finley MFA, Qin N, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Wall MJ, et al. Among authors: lubin ml. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. doi: 10.1016/j.bmcl.2018.10.007. Epub 2018 Oct 12. Bioorg Med Chem Lett. 2018. PMID: 30337231
Attenuated cold sensitivity in TRPM8 null mice.
Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N. Colburn RW, et al. Among authors: lubin ml. Neuron. 2007 May 3;54(3):379-86. doi: 10.1016/j.neuron.2007.04.017. Neuron. 2007. PMID: 17481392 Free article.
17 results