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Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists.
Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ. Latacz G, et al. Among authors: lubelska a. Medchemcomm. 2018 Sep 25;9(11):1882-1890. doi: 10.1039/c8md00313k. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30568756 Free PMC article.
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.
Kucwaj-Brysz K, Warszycki D, Podlewska S, Witek J, Witek K, González Izquierdo A, Satała G, Loza MI, Lubelska A, Latacz G, Bojarski AJ, Castro M, Kieć-Kononowicz K, Handzlik J. Kucwaj-Brysz K, et al. Among authors: lubelska a. Eur J Med Chem. 2016 Apr 13;112:258-269. doi: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9. Eur J Med Chem. 2016. PMID: 26900658
In the search for a lead structure among series of potent and selective hydantoin 5-HT7 R agents: The drug-likeness in vitro study.
Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Sobiło A, Olejarz A, Kucwaj-Brysz K, Satała G, Bojarski AJ, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Latacz G, et al. Among authors: lubelska a. Chem Biol Drug Des. 2017 Dec;90(6):1295-1306. doi: 10.1111/cbdd.13106. Epub 2017 Oct 3. Chem Biol Drug Des. 2017. PMID: 28886235
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.
Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Kucwaj-Brysz K, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Latacz G, et al. Among authors: lubelska a. Bioorg Med Chem Lett. 2018 Mar 1;28(5):878-883. doi: 10.1016/j.bmcl.2018.02.003. Epub 2018 Feb 3. Bioorg Med Chem Lett. 2018. PMID: 29439902
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.
Kurczab R, Ali W, Łażewska D, Kotańska M, Jastrzębska-Więsek M, Satała G, Więcek M, Lubelska A, Latacz G, Partyka A, Starek M, Dąbrowska M, Wesołowska A, Jacob C, Kieć-Kononowicz K, Handzlik J. Kurczab R, et al. Among authors: lubelska a. Molecules. 2018 Oct 3;23(10):2529. doi: 10.3390/molecules23102529. Molecules. 2018. PMID: 30282913 Free PMC article.
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
Ali W, Więcek M, Łażewska D, Kurczab R, Jastrzębska-Więsek M, Satała G, Kucwaj-Brysz K, Lubelska A, Głuch-Lutwin M, Mordyl B, Siwek A, Nasim MJ, Partyka A, Sudoł S, Latacz G, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Ali W, et al. Among authors: lubelska a. Eur J Med Chem. 2019 Sep 15;178:740-751. doi: 10.1016/j.ejmech.2019.06.022. Epub 2019 Jun 10. Eur J Med Chem. 2019. PMID: 31229876
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.
Latacz G, Lubelska A, Jastrzębska-Więsek M, Partyka A, Marć MA, Satała G, Wilczyńska D, Kotańska M, Więcek M, Kamińska K, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Latacz G, et al. Among authors: lubelska a. Int J Mol Sci. 2019 Jul 12;20(14):3420. doi: 10.3390/ijms20143420. Int J Mol Sci. 2019. PMID: 31336820 Free PMC article.
Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.
Lubelska A, Latacz G, Jastrzębska-Więsek M, Kotańska M, Kurczab R, Partyka A, Marć MA, Wilczyńska D, Doroz-Płonka A, Łażewska D, Wesołowska A, Kieć-Kononowicz K, Handzlik J. Lubelska A, et al. Molecules. 2019 Dec 6;24(24):4472. doi: 10.3390/molecules24244472. Molecules. 2019. PMID: 31817628 Free PMC article.
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