Lubbe L - Search Results

1

The Angiotensin AT₂ Receptor: From a Binding Site to a Novel Therapeutic Target.

Steckelings UM, Widdop RE, Sturrock ED, Lubbe L, Hussain T, Kaschina E, Unger T, Hallberg A, Carey RM, Sumners C. Steckelings UM, et al. Among authors: lubbe l. Pharmacol Rev. 2022 Oct;74(4):1051-1135. doi: 10.1124/pharmrev.120.000281. Pharmacol Rev. 2022. PMID: 36180112 Free PMC article. Review.

2

The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition.

Lubbe L, Sewell BT, Sturrock ED. Lubbe L, et al. FEBS J. 2016 Nov;283(21):3941-3961. doi: 10.1111/febs.13900. Epub 2016 Oct 5. FEBS J. 2016. PMID: 27636235 Free article.

3

Angiotensin-converting enzyme open for business: structural insights into the subdomain dynamics.

Cozier GE, Lubbe L, Sturrock ED, Acharya KR. Cozier GE, et al. Among authors: lubbe l. FEBS J. 2021 Apr;288(7):2238-2256. doi: 10.1111/febs.15601. Epub 2020 Nov 2. FEBS J. 2021. PMID: 33067882 Free PMC article.

4

Interacting cogs in the machinery of the renin angiotensin system.

Lubbe L, Sturrock ED. Lubbe L, et al. Biophys Rev. 2019 Jun 8;11(4):583-589. doi: 10.1007/s12551-019-00555-w. Online ahead of print. Biophys Rev. 2019. PMID: 31177382 Free PMC article. Review.

5

ACE-domain selectivity extends beyond direct interacting residues at the active site.

Cozier GE, Lubbe L, Sturrock ED, Acharya KR. Cozier GE, et al. Among authors: lubbe l. Biochem J. 2020 Apr 17;477(7):1241-1259. doi: 10.1042/BCJ20200060. Biochem J. 2020. PMID: 32195541 Free PMC article.

6

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors.

Douglas RG, Sharma RK, Masuyer G, Lubbe L, Zamora I, Acharya KR, Chibale K, Sturrock ED. Douglas RG, et al. Among authors: lubbe l. Clin Sci (Lond). 2014 Feb;126(4):305-13. doi: 10.1042/CS20130403. Clin Sci (Lond). 2014. PMID: 24015848 Free PMC article.

7

Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.

Lubbe L, Sewell BT, Woodward JD, Sturrock ED. Lubbe L, et al. EMBO J. 2022 Aug 16;41(16):e110550. doi: 10.15252/embj.2021110550. Epub 2022 Jul 12. EMBO J. 2022. PMID: 35818993 Free PMC article.

8

ACE2 and ACE: structure-based insights into mechanism, regulation and receptor recognition by SARS-CoV.

Lubbe L, Cozier GE, Oosthuizen D, Acharya KR, Sturrock ED. Lubbe L, et al. Clin Sci (Lond). 2020 Nov 13;134(21):2851-2871. doi: 10.1042/CS20200899. Clin Sci (Lond). 2020. PMID: 33146371 Free PMC article. Review.

9

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).

Sturrock ED, Lubbe L, Cozier GE, Schwager SLU, Arowolo AT, Arendse LB, Belcher E, Acharya KR. Sturrock ED, et al. Among authors: lubbe l. Biochem J. 2019 May 31;476(10):1553-1570. doi: 10.1042/BCJ20190290. Biochem J. 2019. PMID: 31072910

10

Epitope mapping of novel monoclonal antibodies to human angiotensin I-converting enzyme.

Popova IA, Lubbe L, Petukhov PA, Kalantarov GF, Trakht IN, Chernykh ER, Leplina OY, Lyubimov AV, Garcia JGN, Dudek SM, Sturrock ED, Danilov SM. Popova IA, et al. Among authors: lubbe l. Protein Sci. 2021 Aug;30(8):1577-1593. doi: 10.1002/pro.4091. Epub 2021 May 11. Protein Sci. 2021. PMID: 33931897 Free PMC article.

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