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Quinoline is more genotoxic than 4-methylquinoline in hiHeps cells and rodent liver.
Zhang X, Zhao T, Liu W, Xi J, Yao D, Cao Y, You X, Wu J, Gao Z, Lei Y, Zhou C, Zhang X, Zheng J, Luan Y. Zhang X, et al. Among authors: luan y. Mutat Res Genet Toxicol Environ Mutagen. 2023 Feb-Mar;886:503582. doi: 10.1016/j.mrgentox.2022.503582. Epub 2022 Dec 29. Mutat Res Genet Toxicol Environ Mutagen. 2023. PMID: 36868699
Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow®) in China.
Chang Y, Zhou C, Huang F, Torous DK, Luan Y, Shi C, Wang H, Wang X, Wei N, Xia Z, Zhong Z, Zhang M, An F, Cao Y, Geng X, Jiang Y, Ju Q, Yu Y, Zhu J, Dertinger SD, Li B, Liao M, Yuan B, Zhang T, Yu J, Zhang Z, Wang Q, Ma J. Chang Y, et al. Among authors: luan y. Mutat Res Genet Toxicol Environ Mutagen. 2014 Sep 15;772:6-13. doi: 10.1016/j.mrgentox.2014.04.027. Epub 2014 Jul 23. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 25308541
A population study using the human erythrocyte PIG-A assay.
Cao Y, Yang L, Feng N, Shi O, Xi J, You X, Yin C, Yang H, Horibata K, Honma M, Qian B, Weng W, Luan Y. Cao Y, et al. Among authors: luan y. Environ Mol Mutagen. 2016 Oct;57(8):605-614. doi: 10.1002/em.22040. Epub 2016 Sep 1. Environ Mol Mutagen. 2016. PMID: 27581231
Detoxification of benzo[a]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver.
Wang L, Xu W, Ma L, Zhang S, Zhang K, Ye P, Xing G, Zhang X, Cao Y, Xi J, Gu J, Luan Y. Wang L, et al. Among authors: luan y. J Biochem Mol Toxicol. 2017 Jul;31(7). doi: 10.1002/jbt.21902. Epub 2017 Jan 23. J Biochem Mol Toxicol. 2017. PMID: 28111842
1,342 results