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VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
Lee C, Chen R, Sun G, Liu X, Lin X, He C, Xing L, Liu L, Jensen LD, Kumar A, Langer HF, Ren X, Zhang J, Huang L, Yin X, Kim J, Zhu J, Huang G, Li J, Lu W, Chen W, Liu J, Hu J, Sun Q, Lu W, Fang L, Wang S, Kuang H, Zhang Y, Tian G, Mi J, Kang BA, Narazaki M, Prodeus A, Schoonjans L, Ornitz DM, Gariepy J, Eelen G, Dewerchin M, Yang Y, Ou JS, Mora A, Yao J, Zhao C, Liu Y, Carmeliet P, Cao Y, Li X. Lee C, et al. Among authors: lu w. Signal Transduct Target Ther. 2023 Aug 18;8(1):305. doi: 10.1038/s41392-023-01539-9. Signal Transduct Target Ther. 2023. PMID: 37591843 Free PMC article.
VEGF-B is a potent antioxidant.
Arjunan P, Lin X, Tang Z, Du Y, Kumar A, Liu L, Yin X, Huang L, Chen W, Chen Q, Ye Z, Wang S, Kuang H, Zhou L, Xu K, Chen X, Zeng H, Lu W, Cao Y, Liu Y, Zhao C, Li X. Arjunan P, et al. Among authors: lu w. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10351-10356. doi: 10.1073/pnas.1801379115. Epub 2018 Sep 24. Proc Natl Acad Sci U S A. 2018. PMID: 30249667 Free PMC article.
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.
Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, Ye Z, Huang L, Wang S, Ren X, Xing L, Chen W, Huang D, Gao Z, Zhang S, Lu W, Tang Z, Wang B, Ju R, Li X. Zheng L, et al. Among authors: lu w. Oncotarget. 2016 Nov 22;7(47):77902-77915. doi: 10.18632/oncotarget.12843. Oncotarget. 2016. PMID: 27788490 Free PMC article.
PDGFD switches on stem cell endothelial commitment.
Lu W, Xu P, Deng B, Zhang J, Zhan Y, Lin X, Xu X, Xia Z, Yang X, Zeng X, Huang L, Xie B, Wang C, Wang S, Kuang H, Han X, Mora A, Cao Y, Jiang Q, Li X. Lu W, et al. Angiogenesis. 2022 Nov;25(4):517-533. doi: 10.1007/s10456-022-09847-4. Epub 2022 Jul 20. Angiogenesis. 2022. PMID: 35859222 Free PMC article.
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.
Dumas SJ, Meta E, Borri M, Goveia J, Rohlenova K, Conchinha NV, Falkenberg K, Teuwen LA, de Rooij L, Kalucka J, Chen R, Khan S, Taverna F, Lu W, Parys M, De Legher C, Vinckier S, Karakach TK, Schoonjans L, Lin L, Bolund L, Dewerchin M, Eelen G, Rabelink TJ, Li X, Luo Y, Carmeliet P. Dumas SJ, et al. Among authors: lu w. J Am Soc Nephrol. 2020 Jan;31(1):118-138. doi: 10.1681/ASN.2019080832. Epub 2019 Dec 9. J Am Soc Nephrol. 2020. PMID: 31818909 Free PMC article.
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