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Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors.
Lu W, Fan M, Ji W, Tse J, You I, Ficarro SB, Tavares I, Che J, Kim AY, Zhu X, Boghossian A, Rees MG, Ronan MM, Roth JA, Hinshaw SM, Nabet B, Corsello SM, Kwiatkowski N, Marto JA, Zhang T, Gray NS. Lu W, et al. J Med Chem. 2023 Apr 13;66(7):4617-4632. doi: 10.1021/acs.jmedchem.2c01548. Epub 2023 Mar 22. J Med Chem. 2023. PMID: 36946421 Free PMC article.
Discovery and resistance mechanism of a selective CDK12 degrader.
Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS. Jiang B, et al. Among authors: lu w. Nat Chem Biol. 2021 Jun;17(6):675-683. doi: 10.1038/s41589-021-00765-y. Epub 2021 Mar 22. Nat Chem Biol. 2021. PMID: 33753926 Free PMC article.
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
Du G, Jiang J, Wu Q, Henning NJ, Donovan KA, Yue H, Che J, Lu W, Fischer ES, Bardeesy N, Zhang T, Gray NS. Du G, et al. Among authors: lu w. Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15905-15911. doi: 10.1002/anie.202101328. Epub 2021 Jun 14. Angew Chem Int Ed Engl. 2021. PMID: 33915015 Free PMC article.
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain.
Lu T, Lu H, Duan Z, Wang J, Han J, Xiao S, Chen H, Jiang H, Chen Y, Yang F, Li Q, Chen D, Lin J, Li B, Jiang H, Chen K, Lu W, Lin H, Luo C. Lu T, et al. Among authors: lu w, lu h. J Med Chem. 2021 Aug 26;64(16):12075-12088. doi: 10.1021/acs.jmedchem.1c00721. Epub 2021 Aug 10. J Med Chem. 2021. PMID: 34375106
Fragment-based covalent ligand discovery.
Lu W, Kostic M, Zhang T, Che J, Patricelli MP, Jones LH, Chouchani ET, Gray NS. Lu W, et al. RSC Chem Biol. 2021 Feb 9;2(2):354-367. doi: 10.1039/d0cb00222d. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458789 Free PMC article. Review.
Correction: Fragment-based covalent ligand discovery.
Lu W, Kostic M, Zhang T, Che J, Patricelli MP, Jones LH, Chouchani ET, Gray NS. Lu W, et al. RSC Chem Biol. 2021 Feb 22;2(2):670-671. doi: 10.1039/d1cb90008k. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34459829 Free PMC article.
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
Fan M, Lu W, Che J, Kwiatkowski NP, Gao Y, Seo HS, Ficarro SB, Gokhale PC, Liu Y, Geffken EA, Lakhani J, Song K, Kuljanin M, Ji W, Jiang J, He Z, Tse J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Mancias JD, Marto JA, Dhe-Paganon S, Zhang T, Gray NS. Fan M, et al. Among authors: lu w. Elife. 2022 Oct 27;11:e78810. doi: 10.7554/eLife.78810. Elife. 2022. PMID: 36300789 Free PMC article.
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