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Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.
Lu M, Breyssens H, Salter V, Zhong S, Hu Y, Baer C, Ratnayaka I, Sullivan A, Brown NR, Endicott J, Knapp S, Kessler BM, Middleton MR, Siebold C, Jones EY, Sviderskaya EV, Cebon J, John T, Caballero OL, Goding CR, Lu X. Lu M, et al. Among authors: lu x. Cancer Cell. 2013 May 13;23(5):618-33. doi: 10.1016/j.ccr.2013.03.013. Epub 2013 Apr 25. Cancer Cell. 2013. PMID: 23623661 Free article.
Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor.
Chen XJ, Zhang WN, Chen B, Xi WD, Lu Y, Huang JY, Wang YY, Long J, Wu SF, Zhang YX, Wang S, Li SX, Yin T, Lu M, Xi XD, Li JM, Wang KK, Chen Z, Chen SJ. Chen XJ, et al. Among authors: lu y, lu m. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2220-2225. doi: 10.1073/pnas.1818539116. Epub 2019 Jan 18. Proc Natl Acad Sci U S A. 2019. PMID: 30659143 Free PMC article.
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Chen S, Wu J, Zhong S, Li Y, Zhang P, Ma J, Ren J, Tan Y, Wang Y, Au KF, Siebold C, Bond GL, Chen Z, Lu M, Jones EY, Lu X. Chen S, et al. Among authors: lu x, lu m. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17470-17479. doi: 10.1073/pnas.1909393116. Epub 2019 Aug 8. Proc Natl Acad Sci U S A. 2019. PMID: 31395738 Free PMC article.
CDK9 inhibitors reactivate p53 by downregulating iASPP.
Wu J, Liang Y, Tan Y, Tang Y, Song H, Wang Z, Li Y, Lu M. Wu J, et al. Among authors: lu m. Cell Signal. 2020 Mar;67:109508. doi: 10.1016/j.cellsig.2019.109508. Epub 2019 Dec 19. Cell Signal. 2020. PMID: 31866490
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