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A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis.
Ostkamp P, Deffner M, Schulte-Mecklenbeck A, Wünsch C, Lu IN, Wu GF, Goelz S, De Jager PL, Kuhlmann T, Gross CC, Klotz L, Meyer Zu Hörste G, Wiendl H, Schneider-Hohendorf T, Schwab N. Ostkamp P, et al. Among authors: lu in. Sci Transl Med. 2022 Nov 30;14(673):eadc9778. doi: 10.1126/scitranslmed.adc9778. Epub 2022 Nov 30. Sci Transl Med. 2022. PMID: 36449599
Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response.
Teschner VE, Fleck AK, Walter C, Schwarze AS, Eschborn M, Wirth T, Steinberg OV, Schulte-Mecklenbeck A, Lu IN, Herrera-Rivero M, Janoschka C, Lünemann JD, Schwab N, Meyer Zu Hörste G, Varghese J, Gross CC, Pul R, Kleinschnitz C, Mader S, Meinl E, Stoll M, Wiendl H, Klotz L. Teschner VE, et al. Among authors: lu in. Ther Adv Neurol Disord. 2023 Dec 9;16:17562864231211077. doi: 10.1177/17562864231211077. eCollection 2023. Ther Adv Neurol Disord. 2023. PMID: 38084102 Free PMC article.
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
Gunst JD, Pahus MH, Rosás-Umbert M, Lu IN, Benfield T, Nielsen H, Johansen IS, Mohey R, Østergaard L, Klastrup V, Khan M, Schleimann MH, Olesen R, Støvring H, Denton PW, Kinloch NN, Copertino DC, Ward AR, Alberto WDC, Nielsen SD, Puertas MC, Ramos V, Reeves JD, Petropoulos CJ, Martinez-Picado J, Brumme ZL, Jones RB, Fox J, Tolstrup M, Nussenzweig MC, Caskey M, Fidler S, Søgaard OS. Gunst JD, et al. Among authors: lu in. Nat Med. 2022 Nov;28(11):2424-2435. doi: 10.1038/s41591-022-02023-7. Epub 2022 Oct 17. Nat Med. 2022. PMID: 36253609 Free PMC article. Clinical Trial.
Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.
Heming M, Haessner S, Wolbert J, Lu IN, Li X, Brokinkel B, Müther M, Holling M, Stummer W, Thomas C, Schulte-Mecklenbeck A, de Faria F, Stoeckius M, Hailfinger S, Lenz G, Kerl K, Wiendl H, Meyer Zu Hörste G, Grauer OM. Heming M, et al. Among authors: lu in. Genome Med. 2022 Sep 24;14(1):109. doi: 10.1186/s13073-022-01110-1. Genome Med. 2022. PMID: 36153593 Free PMC article.
Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation.
Hartlehnert M, Börsch AL, Li X, Burmeister M, Gerwien H, Schafflick D, Heming M, Lu IN, Narayanan V, Strecker JK, Kolz A, Peters A, Wu GF, Wiendl H, Sorokin L, Meyer Zu Horste G. Hartlehnert M, et al. Among authors: lu in. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2023174118. doi: 10.1073/pnas.2023174118. Proc Natl Acad Sci U S A. 2021. PMID: 34479995 Free PMC article.
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.
Schafflick D, Wolbert J, Heming M, Thomas C, Hartlehnert M, Börsch AL, Ricci A, Martín-Salamanca S, Li X, Lu IN, Pawlak M, Minnerup J, Strecker JK, Seidenbecher T, Meuth SG, Hidalgo A, Liesz A, Wiendl H, Meyer Zu Horste G. Schafflick D, et al. Among authors: lu in. Nat Neurosci. 2021 Sep;24(9):1225-1234. doi: 10.1038/s41593-021-00880-y. Epub 2021 Jul 12. Nat Neurosci. 2021. PMID: 34253922
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid.
Heming M, Li X, Räuber S, Mausberg AK, Börsch AL, Hartlehnert M, Singhal A, Lu IN, Fleischer M, Szepanowski F, Witzke O, Brenner T, Dittmer U, Yosef N, Kleinschnitz C, Wiendl H, Stettner M, Meyer Zu Hörste G. Heming M, et al. Among authors: lu in. Immunity. 2021 Jan 12;54(1):164-175.e6. doi: 10.1016/j.immuni.2020.12.011. Epub 2020 Dec 23. Immunity. 2021. PMID: 33382973 Free PMC article.
23 results