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The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B. Deng M, et al. Among authors: lu b. Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. Epub 2018 Oct 9. Immunity. 2018. PMID: 30314759 Free PMC article.
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.
Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al-Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U, Tracey KJ. Yang H, et al. Among authors: lu b. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7. doi: 10.1073/pnas.1003893107. Epub 2010 Jun 14. Proc Natl Acad Sci U S A. 2010. PMID: 20547845 Free PMC article.
Novel role of PKR in inflammasome activation and HMGB1 release.
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Lu B, et al. Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290. Nature. 2012. PMID: 22801494 Free PMC article.
Regulation of HMGB1 release by inflammasomes.
Lu B, Wang H, Andersson U, Tracey KJ. Lu B, et al. Protein Cell. 2013 Mar;4(3):163-7. doi: 10.1007/s13238-012-2118-2. Epub 2013 Mar 13. Protein Cell. 2013. PMID: 23483477 Free PMC article. Review.
HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors.
Valdés-Ferrer SI, Rosas-Ballina M, Olofsson PS, Lu B, Dancho ME, Ochani M, Li JH, Scheinerman JA, Katz DA, Levine YA, Hudson LK, Yang H, Pavlov VA, Roth J, Blanc L, Antoine DJ, Chavan SS, Andersson U, Diamond B, Tracey KJ. Valdés-Ferrer SI, et al. Among authors: lu b. J Intern Med. 2013 Oct;274(4):381-90. doi: 10.1111/joim.12104. Epub 2013 Aug 12. J Intern Med. 2013. PMID: 23808943 Free PMC article.
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Kang R, Zhang Q, Hou W, Yan Z, Chen R, Bonaroti J, Bansal P, Billiar TR, Tsung A, Wang Q, Bartlett DL, Whitcomb DC, Chang EB, Zhu X, Wang H, Lu B, Tracey KJ, Cao L, Fan XG, Lotze MT, Zeh HJ 3rd, Tang D. Kang R, et al. Among authors: lu b. Gastroenterology. 2014 Apr;146(4):1097-107. doi: 10.1053/j.gastro.2013.12.015. Epub 2013 Dec 17. Gastroenterology. 2014. PMID: 24361123 Free PMC article.
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation.
Lu B, Antoine DJ, Kwan K, Lundbäck P, Wähämaa H, Schierbeck H, Robinson M, Van Zoelen MA, Yang H, Li J, Erlandsson-Harris H, Chavan SS, Wang H, Andersson U, Tracey KJ. Lu B, et al. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3068-73. doi: 10.1073/pnas.1316925111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469805 Free PMC article.
6,646 results