Lowther WT - Search Results

1

Fatty acid synthase inhibitors: new directions for oncology.

Kridel SJ, Lowther WT, Pemble CW 4th. Kridel SJ, et al. Among authors: lowther wt. Expert Opin Investig Drugs. 2007 Nov;16(11):1817-29. doi: 10.1517/13543784.16.11.1817. Expert Opin Investig Drugs. 2007. PMID: 17970640 Review.

2

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat.

Pemble CW 4th, Johnson LC, Kridel SJ, Lowther WT. Pemble CW 4th, et al. Among authors: lowther wt. Nat Struct Mol Biol. 2007 Aug;14(8):704-9. doi: 10.1038/nsmb1265. Epub 2007 Jul 8. Nat Struct Mol Biol. 2007. PMID: 17618296

3

Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.

Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW 4th, Fulp BE, Furdui CM, Kridel SJ, Lowther WT. Ritchie MK, et al. Among authors: lowther wt. J Biol Chem. 2016 Feb 12;291(7):3520-30. doi: 10.1074/jbc.M115.702597. Epub 2015 Dec 9. J Biol Chem. 2016. PMID: 26663084 Free PMC article.

4

Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.

Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM. Hill TK, et al. Among authors: lowther wt. Mol Pharm. 2016 Mar 7;13(3):720-8. doi: 10.1021/acs.molpharmaceut.5b00447. Epub 2016 Feb 8. Mol Pharm. 2016. PMID: 26824142 Free PMC article.

5

Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design.

Murray MS, Holmes RP, Lowther WT. Murray MS, et al. Among authors: lowther wt. Biochemistry. 2008 Feb 26;47(8):2439-49. doi: 10.1021/bi701710r. Epub 2008 Jan 24. Biochemistry. 2008. PMID: 18215067 Free PMC article.

6

Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.

Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LB. Klomsiri C, et al. Among authors: lowther wt. Methods Enzymol. 2010;473:77-94. doi: 10.1016/S0076-6879(10)73003-2. Methods Enzymol. 2010. PMID: 20513472 Free PMC article. Review.

7

4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.

Riedel TJ, Knight J, Murray MS, Milliner DS, Holmes RP, Lowther WT. Riedel TJ, et al. Among authors: lowther wt. Biochim Biophys Acta. 2012 Oct;1822(10):1544-52. doi: 10.1016/j.bbadis.2012.06.014. Epub 2012 Jul 5. Biochim Biophys Acta. 2012. PMID: 22771891 Free PMC article.

8

Reduction of cysteine sulfinic acid in peroxiredoxin by sulfiredoxin proceeds directly through a sulfinic phosphoryl ester intermediate.

Jönsson TJ, Murray MS, Johnson LC, Lowther WT. Jönsson TJ, et al. Among authors: lowther wt. J Biol Chem. 2008 Aug 29;283(35):23846-51. doi: 10.1074/jbc.M803244200. Epub 2008 Jun 24. J Biol Chem. 2008. PMID: 18579529 Free PMC article.

9

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.

Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: lowther wt. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.

10

Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.

Lema Tomé CM, Palma E, Ferluga S, Lowther WT, Hantgan R, Wykosky J, Debinski W. Lema Tomé CM, et al. Among authors: lowther wt. J Biol Chem. 2012 Apr 20;287(17):14012-22. doi: 10.1074/jbc.M111.311670. Epub 2012 Feb 23. J Biol Chem. 2012. PMID: 22362770 Free PMC article.

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