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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW. Lee KL, et al. Among authors: lowe md. J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14. J Med Chem. 2017. PMID: 28498658
Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
Kaila N, Huang A, Moretto A, Follows B, Janz K, Lowe M, Thomason J, Mansour TS, Hubeau C, Page K, Morgan P, Fish S, Xu X, Williams C, Saiah E. Kaila N, et al. J Med Chem. 2012 Jun 14;55(11):5088-109. doi: 10.1021/jm300007n. Epub 2012 May 31. J Med Chem. 2012. PMID: 22651823
Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
Kaila N, Follows B, Leung L, Thomason J, Huang A, Moretto A, Janz K, Lowe M, Mansour TS, Hubeau C, Page K, Morgan P, Fish S, Xu X, Williams C, Saiah E. Kaila N, et al. J Med Chem. 2014 Feb 27;57(4):1299-322. doi: 10.1021/jm401509e. Epub 2014 Feb 10. J Med Chem. 2014. PMID: 24512187
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Huang A, Moretto A, Janz K, Lowe M, Bedard PW, Tam S, Di L, Clerin V, Sushkova N, Tchernychev B, Tsao DH, Keith JC, Shaw GD, Schaub RG, Wang Q, Kaila N. Huang A, et al. J Med Chem. 2010 Aug 26;53(16):6003-17. doi: 10.1021/jm9013696. J Med Chem. 2010. PMID: 20718494
Outcomes From Pediatric Ablation: A Review of 20 Years of National Data.
Walsh MA, Gonzalez CM, Uzun OJ, McMahon CJ, Sadagopan SN, Yue AM, Seller N, Hares DL, Bhole V, Till J, Wong L, Mangat JS, Lowe MD, Rosenthal E, Bowes M, Stuart AG. Walsh MA, et al. Among authors: lowe md. JACC Clin Electrophysiol. 2021 Nov;7(11):1358-1365. doi: 10.1016/j.jacep.2021.03.012. Epub 2021 Jun 30. JACC Clin Electrophysiol. 2021. PMID: 34217658 Free article. Review.
A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK).
Honarbakhsh S, Providencia R, Garcia-Hernandez J, Martin CA, Hunter RJ, Lim WY, Kirkby C, Graham AJ, Sharifzadehgan A, Waldmann V, Marijon E, Munoz-Esparza C, Lacunza J, Gimeno-Blanes JR, Ankou B, Chevalier P, Antonio N, Elvas L, Castelletti S, Crotti L, Schwartz P, Scanavacca M, Darrieux F, Sacilotto L, Mueller-Leisse J, Veltmann C, Vicentini A, Demarchi A, Cortez-Dias N, Antonio PS, de Sousa J, Adragao P, Cavaco D, Costa FM, Khoueiry Z, Boveda S, Sousa MJ, Jebberi Z, Heck P, Mehta S, Conte G, Ozkartal T, Auricchio A, Lowe MD, Schilling RJ, Prieto-Merino D, Lambiase PD; Brugada Syndrome Risk Investigators. Honarbakhsh S, et al. Among authors: lowe md. JACC Clin Electrophysiol. 2021 Feb;7(2):210-222. doi: 10.1016/j.jacep.2020.08.032. Epub 2020 Oct 28. JACC Clin Electrophysiol. 2021. PMID: 33602402 Free article.
Outcome of ACHD patients with non-inducible versus inducible IART undergoing cavo-tricuspid isthmus ablation: the role of empiric ablation.
Sawhney V, Mc Lellan A, Chatha S, Perera D, Aderonke A, Juno S, Whittaker-Axon S, Daw H, Garcia J, Lambiase PD, Cullen S, Bhan A, Von Klemperer K, Walker F, Pandya B, Lowe MD, Ezzat V. Sawhney V, et al. Among authors: lowe md. J Interv Card Electrophysiol. 2021 Jan;60(1):49-56. doi: 10.1007/s10840-019-00692-y. Epub 2020 Jan 29. J Interv Card Electrophysiol. 2021. PMID: 31997041
Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation.
Srinivasan NT, Orini M, Providencia R, Dhinoja MB, Lowe MD, Ahsan SY, Chow AW, Hunter RJ, Schilling RJ, Taggart P, Lambiase PD. Srinivasan NT, et al. Among authors: lowe md. Europace. 2019 Apr 1;21(4):616-625. doi: 10.1093/europace/euy260. Europace. 2019. PMID: 30500897 Free PMC article.
65 results