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Fusarium verticillioides NAT1 (FDB2) N-malonyltransferase is structurally, functionally and phylogenetically distinct from its N-acetyltransferase (NAT) homologues.
Karagianni EP, Kontomina E, Lowe ED, Athanasopoulos K, Papanikolaou G, Garefalaki V, Kotseli V, Zaliou S, Grimaud T, Arvaniti K, Tsatiri MA, Fakis G, Glenn AE, Roversi P, Abuhammad A, Ryan A, Sim RB, Sim E, Boukouvala S. Karagianni EP, et al. Among authors: lowe ed. FEBS J. 2023 May;290(9):2412-2436. doi: 10.1111/febs.16642. Epub 2022 Oct 18. FEBS J. 2023. PMID: 36178468 Free article.
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E. Abuhammad A, et al. Among authors: lowe ed. PLoS One. 2012;7(12):e52790. doi: 10.1371/journal.pone.0052790. Epub 2012 Dec 28. PLoS One. 2012. PMID: 23285185 Free PMC article.
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.
Abuhammad A, Lowe ED, McDonough MA, Shaw Stewart PD, Kolek SA, Sim E, Garman EF. Abuhammad A, et al. Among authors: lowe ed. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1433-46. doi: 10.1107/S0907444913015126. Epub 2013 Jul 17. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23897467
A novel mechanism for azoreduction.
Ryan A, Laurieri N, Westwood I, Wang CJ, Lowe E, Sim E. Ryan A, et al. J Mol Biol. 2010 Jul 2;400(1):24-37. doi: 10.1016/j.jmb.2010.04.023. Epub 2010 Apr 24. J Mol Biol. 2010. PMID: 20417637
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: lowe ed. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
72 results