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The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.
Seng TJ, Low JS, Li H, Cui Y, Goh HK, Wong ML, Srivastava G, Sidransky D, Califano J, Steenbergen RD, Rha SY, Tan J, Hsieh WS, Ambinder RF, Lin X, Chan AT, Tao Q. Seng TJ, et al. Oncogene. 2007 Feb 8;26(6):934-44. doi: 10.1038/sj.onc.1209839. Epub 2006 Jul 24. Oncogene. 2007. PMID: 16862168