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The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.
Kryza T, Bock N, Lovell S, Rockstroh A, Lehman ML, Lesner A, Panchadsaram J, Silva LM, Srinivasan S, Snell CE, Williams ED, Fazli L, Gleave M, Batra J, Nelson C, Tate EW, Harris J, Hooper JD, Clements JA. Kryza T, et al. Among authors: lovell s. Mol Oncol. 2020 Jan;14(1):105-128. doi: 10.1002/1878-0261.12587. Epub 2019 Nov 28. Mol Oncol. 2020. PMID: 31630475 Free PMC article.
Faecal neutrophil elastase-antiprotease balance reflects colitis severity.
Barry R, Ruano-Gallego D, Radhakrishnan ST, Lovell S, Yu L, Kotik O, Glegola-Madejska I, Tate EW, Choudhary JS, Williams HRT, Frankel G. Barry R, et al. Among authors: lovell s. Mucosal Immunol. 2020 Mar;13(2):322-333. doi: 10.1038/s41385-019-0235-4. Epub 2019 Nov 26. Mucosal Immunol. 2020. PMID: 31772324 Free PMC article.
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.
Simões BM, Santiago-Gómez A, Chiodo C, Moreira T, Conole D, Lovell S, Alferez D, Eyre R, Spence K, Sarmiento-Castro A, Kohler B, Morisset L, Lanzino M, Andò S, Marangoni E, Sims AH, Tate EW, Howell SJ, Clarke RB. Simões BM, et al. Among authors: lovell s. Oncogene. 2020 Jun;39(25):4896-4908. doi: 10.1038/s41388-020-1335-z. Epub 2020 May 30. Oncogene. 2020. PMID: 32472077 Free PMC article.
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1.
Kryza T, Khan T, Lovell S, Harrington BS, Yin J, Porazinski S, Pajic M, Koistinen H, Rantala JK, Dreyer T, Magdolen V, Reuning U, He Y, Tate EW, Hooper JD. Kryza T, et al. Among authors: lovell s. Nat Chem Biol. 2021 Jul;17(7):776-783. doi: 10.1038/s41589-021-00783-w. Epub 2021 Apr 15. Nat Chem Biol. 2021. PMID: 33859413
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
Steuten K, Kim H, Widen JC, Babin BM, Onguka O, Lovell S, Bolgi O, Cerikan B, Neufeldt CJ, Cortese M, Muir RK, Bennett JM, Geiss-Friedlander R, Peters C, Bartenschlager R, Bogyo M. Steuten K, et al. Among authors: lovell s. ACS Infect Dis. 2021 Jun 11;7(6):1457-1468. doi: 10.1021/acsinfecdis.0c00815. Epub 2021 Feb 11. ACS Infect Dis. 2021. PMID: 33570381 Free PMC article.
354 results