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Targeting sphingosine-1-phosphate receptors in cancer.
Watters RJ, Wang HG, Sung SS, Loughran TP, Liu X. Watters RJ, et al. Among authors: loughran tp. Anticancer Agents Med Chem. 2011 Nov;11(9):810-7. doi: 10.2174/187152011797655041. Anticancer Agents Med Chem. 2011. PMID: 21707490 Free PMC article. Review.
Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.
Barth BM, Wang W, Toran PT, Fox TE, Annageldiyev C, Ondrasik RM, Keasey NR, Brown TJ, Devine VG, Sullivan EC, Cote AL, Papakotsi V, Tan SF, Shanmugavelandy SS, Deering TG, Needle DB, Stern ST, Zhu J, Liao J, Viny AD, Feith DJ, Levine RL, Wang HG, Loughran TP Jr, Sharma A, Kester M, Claxton DF. Barth BM, et al. Among authors: loughran tp jr. Blood Adv. 2019 Sep 10;3(17):2598-2603. doi: 10.1182/bloodadvances.2018021295. Blood Adv. 2019. PMID: 31488436 Free PMC article.
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation.
Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP Jr, Sebti S, Wang HG. Doi K, et al. Among authors: loughran tp jr. J Biol Chem. 2012 Mar 23;287(13):10224-10235. doi: 10.1074/jbc.M111.334532. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311987 Free PMC article.
Acid ceramidase is upregulated in AML and represents a novel therapeutic target.
Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, Liao J, Yun J, Kester M, Claxton DF, Wang HG, Cabot MC, Schuchman EH, Levine RL, Feith DJ, Loughran TP Jr. Tan SF, et al. Among authors: loughran tp jr. Oncotarget. 2016 Dec 13;7(50):83208-83222. doi: 10.18632/oncotarget.13079. Oncotarget. 2016. PMID: 27825124 Free PMC article.
Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.
Liao A, Broeg K, Fox T, Tan SF, Watters R, Shah MV, Zhang LQ, Li Y, Ryland L, Yang J, Aliaga C, Dewey A, Rogers A, Loughran K, Hirsch L, Jarbadan NR, Baab KT, Liao J, Wang HG, Kester M, Desai D, Amin S, Loughran TP Jr, Liu X. Liao A, et al. Among authors: loughran k, loughran tp jr. Blood. 2011 Sep 8;118(10):2793-800. doi: 10.1182/blood-2011-01-331447. Epub 2011 Jul 18. Blood. 2011. PMID: 21768294 Free PMC article.
292 results