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Novel pathological variants of NHP2 affect N-terminal domain flexibility, protein stability, H/ACA Ribonucleoprotein (RNP) complex formation and telomerase activity.
Maliński B, Vertemara J, Faustini E, Ladenvall C, Norberg A, Zhang Y, von Castelmur E, Baliakas P, Tisi R, Cammenga J, Lottersberger F. Maliński B, et al. Among authors: lottersberger f. Hum Mol Genet. 2023 Sep 16;32(19):2901-2912. doi: 10.1093/hmg/ddad114. Hum Mol Genet. 2023. PMID: 37440454 Free PMC article.
The risky business of ADP-ribosylating telomeric DNA.
Doksani Y, Lottersberger F. Doksani Y, et al. Among authors: lottersberger f. Nat Struct Mol Biol. 2024 May;31(5):737-738. doi: 10.1038/s41594-024-01285-8. Nat Struct Mol Biol. 2024. PMID: 38714888 No abstract available.
DNA-PK controls Apollo's access to leading-end telomeres.
Sonmez C, Toia B, Eickhoff P, Matei AM, El Beyrouthy M, Wallner B, Douglas ME, de Lange T, Lottersberger F. Sonmez C, et al. Among authors: lottersberger f. Nucleic Acids Res. 2024 May 8;52(8):4313-4327. doi: 10.1093/nar/gkae105. Nucleic Acids Res. 2024. PMID: 38407308 Free PMC article.
DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres.
Myler LR, Toia B, Vaughan CK, Takai K, Matei AM, Wu P, Paull TT, de Lange T, Lottersberger F. Myler LR, et al. Among authors: lottersberger f. Nat Struct Mol Biol. 2023 Sep;30(9):1346-1356. doi: 10.1038/s41594-023-01072-x. Epub 2023 Aug 31. Nat Struct Mol Biol. 2023. PMID: 37653239 Free PMC article.
14 results