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Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I. Puris E, et al. Among authors: loryan i. Mol Pharm. 2019 Jul 1;16(7):3261-3274. doi: 10.1021/acs.molpharmaceut.9b00502. Epub 2019 Jun 18. Mol Pharm. 2019. PMID: 31180686
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.
Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development.
Loryan I, Hoppe E, Hansen K, Held F, Kless A, Linz K, Marossek V, Nolte B, Ratcliffe P, Saunders D, Terlinden R, Wegert A, Welbers A, Will O, Hammarlund-Udenaes M. Loryan I, et al. Mol Pharm. 2017 Dec 4;14(12):4362-4373. doi: 10.1021/acs.molpharmaceut.7b00480. Epub 2017 Nov 3. Mol Pharm. 2017. PMID: 29099189
26 results