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Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.
Nardella F, Dobrescu I, Hassan H, Rodrigues F, Thiberge S, Mancio-Silva L, Tafit A, Jallet C, Cadet-Daniel V, Goussin S, Lorthiois A, Menon Y, Molinier N, Pechalrieu D, Long C, Sautel F, Matondo M, Duchateau M, Médard G, Witkowski B, Scherf A, Halby L, Arimondo PB. Nardella F, et al. Among authors: lorthiois a. iScience. 2023 Jan 11;26(2):105940. doi: 10.1016/j.isci.2023.105940. eCollection 2023 Feb 17. iScience. 2023. PMID: 36718363 Free PMC article.
Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission.
Singh P, Alaganan A, More KR, Lorthiois A, Thiberge S, Gorgette O, Guillotte Blisnick M, Guglielmini J, Aguilera SS, Touqui L, Singh S, Chitnis CE. Singh P, et al. Among authors: lorthiois a. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17498-17508. doi: 10.1073/pnas.1900266116. Epub 2019 Aug 14. Proc Natl Acad Sci U S A. 2019. PMID: 31413195 Free PMC article.
Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R. Bargieri DY, et al. Among authors: lorthiois a. Cell Host Microbe. 2016 Nov 9;20(5):618-630. doi: 10.1016/j.chom.2016.10.015. Cell Host Microbe. 2016. PMID: 27832590 Free PMC article.
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures.
Dembélé L, Franetich JF, Lorthiois A, Gego A, Zeeman AM, Kocken CH, Le Grand R, Dereuddre-Bosquet N, van Gemert GJ, Sauerwein R, Vaillant JC, Hannoun L, Fuchter MJ, Diagana TT, Malmquist NA, Scherf A, Snounou G, Mazier D. Dembélé L, et al. Among authors: lorthiois a. Nat Med. 2014 Mar;20(3):307-12. doi: 10.1038/nm.3461. Epub 2014 Feb 9. Nat Med. 2014. PMID: 24509527
Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis.
Neveu G, Richard C, Dupuy F, Behera P, Volpe F, Subramani PA, Marcel-Zerrougui B, Vallin P, Andrieu M, Minz AM, Azar N, Martins RM, Lorthiois A, Gazeau F, Lopez-Rubio JJ, Mazier D, Silva AKA, Satpathi S, Wassmer SC, Verdier F, Lavazec C. Neveu G, et al. Among authors: lorthiois a. Blood. 2020 Sep 17;136(12):1381-1393. doi: 10.1182/blood.2019004746. Blood. 2020. PMID: 32589714 Free PMC article.
The Host Protein Aquaporin-9 is Required for Efficient Plasmodium falciparum Sporozoite Entry into Human Hepatocytes.
Amanzougaghene N, Tajeri S, Yalaoui S, Lorthiois A, Soulard V, Gego A, Rametti A, Risco-Castillo V, Moreno A, Tefit M, van Gemert GJ, Sauerwein RW, Vaillant JC, Ravassard P, Pérignon JL, Froissard P, Mazier D, Franetich JF. Amanzougaghene N, et al. Among authors: lorthiois a. Front Cell Infect Microbiol. 2021 Jun 29;11:704662. doi: 10.3389/fcimb.2021.704662. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34268141 Free PMC article.
18 results