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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic A, Brand T, Schanbacher C, Kramer S, Hümmert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knüchel R, Müller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Müller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Tomasovic A, et al. Among authors: lorenz k. Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4. Nat Commun. 2020. PMID: 32265441 Free PMC article.
Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling.
Lorenz K, Schmitt JP, Vidal M, Lohse MJ. Lorenz K, et al. Int J Biochem Cell Biol. 2009 Dec;41(12):2351-5. doi: 10.1016/j.biocel.2009.08.002. Epub 2009 Aug 8. Int J Biochem Cell Biol. 2009. PMID: 19666137 Review.
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Schmid E, et al. Among authors: lorenz k. Nat Med. 2015 Nov;21(11):1298-306. doi: 10.1038/nm.3972. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479924
Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Schmid E, et al. Among authors: lorenz k. Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c. Nat Med. 2016. PMID: 26845407 No abstract available.
Analyzing ERK 1/2 signalling and targets.
Brietz A, Schuch KV, Wangorsch G, Lorenz K, Dandekar T. Brietz A, et al. Among authors: lorenz k. Mol Biosyst. 2016 Jul 19;12(8):2436-46. doi: 10.1039/c6mb00255b. Mol Biosyst. 2016. PMID: 27301697
994 results