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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24.
Nature. 2023.
PMID: 37225977
Free PMC article.
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH.
Eschweiler S, et al. Among authors: lopez guadamillas e.
Nature. 2022 May;605(7911):741-746. doi: 10.1038/s41586-022-04685-2. Epub 2022 May 4.
Nature. 2022.
PMID: 35508656
Free PMC article.
Clinical Trial.
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Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3.
Lauder SN, Smart K, Kersemans V, Allen D, Scott J, Pires A, Milutinovic S, Somerville M, Smart S, Kinchesh P, Lopez-Guadamillas E, Hughes E, Jones E, Scurr M, Godkin A, Friedman LS, Vanhaesebroeck B, Gallimore A.
Lauder SN, et al. Among authors: lopez guadamillas e.
J Immunother Cancer. 2020 Oct;8(2):e000693. doi: 10.1136/jitc-2020-000693.
J Immunother Cancer. 2020.
PMID: 33093155
Free PMC article.
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PI3Kα inhibition reduces obesity in mice.
Lopez-Guadamillas E, Muñoz-Martin M, Martinez S, Pastor J, Fernandez-Marcos PJ, Serrano M.
Lopez-Guadamillas E, et al.
Aging (Albany NY). 2016 Nov 4;8(11):2747-2753. doi: 10.18632/aging.101075.
Aging (Albany NY). 2016.
PMID: 27816049
Free PMC article.
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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.
Bird TG, et al. Among authors: lopez guadamillas e.
Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230.
Sci Transl Med. 2018.
PMID: 30111642
Free PMC article.
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p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα.
Lopez-Guadamillas E, Fernandez-Marcos PJ, Pantoja C, Muñoz-Martin M, Martínez D, Gómez-López G, Campos-Olivas R, Valverde AM, Serrano M.
Lopez-Guadamillas E, et al.
Sci Rep. 2016 Oct 10;6:34542. doi: 10.1038/srep34542.
Sci Rep. 2016.
PMID: 27721423
Free PMC article.
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Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.
Ortega-Molina A, Lopez-Guadamillas E, Mattison JA, Mitchell SJ, Muñoz-Martin M, Iglesias G, Gutierrez VM, Vaughan KL, Szarowicz MD, González-García I, López M, Cebrián D, Martinez S, Pastor J, de Cabo R, Serrano M.
Ortega-Molina A, et al. Among authors: lopez guadamillas e.
Cell Metab. 2015 Apr 7;21(4):558-70. doi: 10.1016/j.cmet.2015.02.017. Epub 2015 Mar 26.
Cell Metab. 2015.
PMID: 25817535
Free PMC article.
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Pten positively regulates brown adipose function, energy expenditure, and longevity.
Ortega-Molina A, Efeyan A, Lopez-Guadamillas E, Muñoz-Martin M, Gómez-López G, Cañamero M, Mulero F, Pastor J, Martinez S, Romanos E, Mar Gonzalez-Barroso M, Rial E, Valverde AM, Bischoff JR, Serrano M.
Ortega-Molina A, et al. Among authors: lopez guadamillas e.
Cell Metab. 2012 Mar 7;15(3):382-94. doi: 10.1016/j.cmet.2012.02.001.
Cell Metab. 2012.
PMID: 22405073
Free article.
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