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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, Capell A, Davis SS, de Weerd L, Dugas JC, Duque J, Earr T, Gadkar K, Giese T, Gill A, Gnörich J, Ha C, Kannuswamy M, Kim DJ, Kunte ST, Kunze LH, Lac D, Lechtenberg K, Leung AW, Liang CC, Lopez I, McQuade P, Modi A, Torres VO, Nguyen HN, Pesämaa I, Propson N, Reich M, Robles-Colmenares Y, Schlepckow K, Slemann L, Solanoy H, Suh JH, Thorne RG, Vieira C, Wind-Mark K, Xiong K, Zuchero YJY, Diaz D, Dennis MS, Huang F, Scearce-Levie K, Watts RJ, Haass C, Lewcock JW, Di Paolo G, Brendel M, Sanchez PE, Monroe KM. van Lengerich B, et al. Among authors: lopez i. Nat Neurosci. 2023 Mar;26(3):416-429. doi: 10.1038/s41593-022-01240-0. Epub 2023 Jan 12. Nat Neurosci. 2023. PMID: 36635496 Free PMC article.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE. Xia D, et al. Among authors: lopez i. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. Mol Neurodegener. 2022. PMID: 35690868 Free PMC article.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
Arguello A, Meisner R, Thomsen ER, Nguyen HN, Ravi R, Simms J, Lo I, Speckart J, Holtzman J, Gill TM, Chan D, Cheng Y, Chiu CL, Dugas JC, Fang M, Lopez IA, Solanoy H, Tsogtbaatar B, Zhu Y, Bhalla A, Henne KR, Henry AG, Delucchi A, Costanzo S, Harris JM, Diaz D, Scearce-Levie K, Sanchez PE. Arguello A, et al. Among authors: lopez ia. JCI Insight. 2021 Oct 8;6(19):e145445. doi: 10.1172/jci.insight.145445. JCI Insight. 2021. PMID: 34622797 Free PMC article.
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L. Johnson ECB, et al. Among authors: lopez i. Mol Neurodegener. 2020 Sep 14;15(1):53. doi: 10.1186/s13024-020-00393-5. Mol Neurodegener. 2020. PMID: 32921309 Free PMC article.
Tau Reduction Prevents Key Features of Autism in Mouse Models.
Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, Guo W, Mucke L. Tai C, et al. Among authors: lopez i. Neuron. 2020 May 6;106(3):421-437.e11. doi: 10.1016/j.neuron.2020.01.038. Epub 2020 Mar 2. Neuron. 2020. PMID: 32126198 Free PMC article.
Extracellular release of mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates GVHD.
Vijayan V, Yan H, Lohmeyer JK, Prentiss KA, Patil RV, Barbarito G, Lopez I, Elezaby A, Peterson K, Baker J, Ostberg NP, Bertaina A, Negrin RS, Mochly-Rosen D, Weinberg KI, Haileselassie B. Vijayan V, et al. Among authors: lopez i. Blood Adv. 2024 May 3:bloodadvances.2023012328. doi: 10.1182/bloodadvances.2023012328. Online ahead of print. Blood Adv. 2024. PMID: 38701354
Integrative Clinical, Hormonal and Molecular Data associate with Invasiveness in Acromegaly: REMAH Study.
Sampedro-Nuñez M, Herrera-Martínez AD, Ibáñez-Costa A, Rivero-Cortés E, Venegas E, Robledo M, Martínez-Hernández R, García-Martínez A, Gil J, Jordà M, López-Fernández J, Gavilán I, Maraver S, Marqués-Pamies M, Cámara R, Fajardo-Montañana C, Valassi E, Dios E, Aulinas A, Biagetti B, Álvarez Escola C, Araujo-Castro M, Blanco C, de Miguel P, Villar-Taibo R, Álvarez CV, Gaztambide S, Webb SM, Castaño L, Bernabéu I, Picó A, Gálvez MÁ, Soto-Moreno A, Puig-Domingo M, Castaño JP, Marazuela M, Luque RM; REMAH investigators. Sampedro-Nuñez M, et al. Eur J Endocrinol. 2024 May 3:lvae045. doi: 10.1093/ejendo/lvae045. Online ahead of print. Eur J Endocrinol. 2024. PMID: 38701338
Knowledge, attitudes and perceptions of Latin American healthcare workers relating to antibiotic stewardship and antibiotic use: a cross-sectional multi-country study.
Fabre V, Cosgrove SE, Lessa FC, Patel TS, Reyes-Morales G, Aleman WR, Alvarez AA, Aquiles B, Arauz AB, Arguello F, Barberis MF, Barcan L, Bernachea MP, Bernan ML, Buitrago C, Del Carmen Bangher M, Castañeda X, Colque AM, Canton A, Contreras R, Correa S, Campero GC, Espinola L, Esquivel C, Ezcurra C, Falleroni LA, Fernandez J, Ferrari S, Frassone N, Cruz CG, Garzón MI, Quintero CHG, Gonzalez JA, Guaymas L, Guerrero-Toapanta F, Lambert S, Laplume D, Lazarte PR, Lemir CG, Lopez A, Lopez IL, Maldonado H, Martinez G, Maurizi DM, Melgar M, Mesplet F, Pertuz CM, Moreno C, Moya GL, Nuccetelli Y, Núñez G, Osuna C, Palacio B, Pellice F, Raffo C, Choto FR, Ricoy G, Rodriguez V, Romero F, Romero JJ, Russo ME, Sadino G, Sandoval N, Silva MG, Urueña AM, Reyes LV, Videla H, Valle M, Perez SVA, Vergara-Samur H, Villamandos S, Villarreal O, Viteri A, Warley E, Quiros RE. Fabre V, et al. Among authors: lopez il. Antimicrob Resist Infect Control. 2024 Apr 26;13(1):47. doi: 10.1186/s13756-024-01400-w. Antimicrob Resist Infect Control. 2024. PMID: 38664757 Free PMC article.
1,075 results