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Progress in targeting the BCL-2 family of proteins.
Garner TP, Lopez A, Reyna DE, Spitz AZ, Gavathiotis E. Garner TP, et al. Among authors: lopez a. Curr Opin Chem Biol. 2017 Aug;39:133-142. doi: 10.1016/j.cbpa.2017.06.014. Epub 2017 Aug 17. Curr Opin Chem Biol. 2017. PMID: 28735187 Free PMC article. Review.
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E. Reyna DE, et al. Among authors: lopez a. Cancer Cell. 2017 Oct 9;32(4):490-505.e10. doi: 10.1016/j.ccell.2017.09.001. Cancer Cell. 2017. PMID: 29017059 Free PMC article.
Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1.
Ow TJ, Fulcher CD, Thomas C, Broin PÓ, López A, Reyna DE, Smith RV, Sarta C, Prystowsky MB, Schlecht NF, Schiff BA, Rosenblatt G, Belbin TJ, Harris TM, Childs GC, Kawachi N, Guha C, Gavathiotis E. Ow TJ, et al. Among authors: lopez a. Oncotarget. 2019 Jan 11;10(4):494-510. doi: 10.18632/oncotarget.26563. eCollection 2019 Jan 11. Oncotarget. 2019. PMID: 30728900 Free PMC article.
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.
Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I. Chen X, et al. Among authors: lopez a. Cancer Discov. 2019 Jul;9(7):890-909. doi: 10.1158/2159-8290.CD-19-0117. Epub 2019 May 2. Cancer Discov. 2019. PMID: 31048321 Free PMC article.
Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma.
Ow TJ, Thomas C, Fulcher CD, Chen J, López A, Reyna DE, Prystowsky MB, Smith RV, Schiff BA, Rosenblatt G, Belbin TJ, Harris TM, Childs GC, Kawachi N, Schlecht NF, Gavathiotis E. Ow TJ, et al. Among authors: lopez a. Laryngoscope. 2020 Nov;130(11):2643-2649. doi: 10.1002/lary.28441. Epub 2020 Jan 2. Laryngoscope. 2020. PMID: 31894587 Free PMC article.
In Response to Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma.
Ow TJ, Thomas C, Fulcher CD, Chen J, López A, Reyna DE, Prystowsky MB, Smith RV, Schiff BA, Rosenblatt G, Belbin TJ, Harris TM, Childs GC, Kawachi N, Schlecht NF, Gavathiotis E. Ow TJ, et al. Among authors: lopez a. Laryngoscope. 2020 Aug;130(8):E458-E459. doi: 10.1002/lary.28719. Epub 2020 May 18. Laryngoscope. 2020. PMID: 32421206 Free PMC article. No abstract available.
A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.
Amgalan D, Garner TP, Pekson R, Jia XF, Yanamandala M, Paulino V, Liang FG, Corbalan JJ, Lee J, Chen Y, Karagiannis GS, Sanchez LR, Liang H, Narayanagari SR, Mitchell K, Lopez A, Margulets V, Scarlata M, Santulli G, Asnani A, Peterson RT, Hazan RB, Condeelis JS, Oktay MH, Steidl U, Kirshenbaum LA, Gavathiotis E, Kitsis RN. Amgalan D, et al. Among authors: lopez a. Nat Cancer. 2020 Mar;1(3):315-328. doi: 10.1038/s43018-020-0039-1. Epub 2020 Mar 2. Nat Cancer. 2020. PMID: 32776015 Free PMC article.
ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.
Rahmani NE, Ramachandra N, Sahu S, Gitego N, Lopez A, Pradhan K, Bhagat TD, Gordon-Mitchell S, Pena BR, Kazemi M, Rao K, Giricz O, Maqbool SB, Olea R, Zhao Y, Zhang J, Dolatshad H, Tittrea V, Tatwavedi D, Singh S, Lee J, Sun T, Steidl U, Shastri A, Inoue D, Abdel-Wahab O, Pellagatti A, Gavathiotis E, Boultwood J, Verma A. Rahmani NE, et al. Among authors: lopez a. Blood Cancer J. 2021 Sep 21;11(9):157. doi: 10.1038/s41408-021-00541-0. Blood Cancer J. 2021. PMID: 34548471 Free PMC article.
5,101 results