Lonial S - Search Results

1

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.

Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H. Mo X, et al. Among authors: lonial s. Cell. 2022 May 26;185(11):1974-1985.e12. doi: 10.1016/j.cell.2022.04.014. Epub 2022 May 4. Cell. 2022. PMID: 35512704 Free PMC article.

2

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. David E, et al. Among authors: lonial s. Blood. 2005 Dec 15;106(13):4322-9. doi: 10.1182/blood-2005-06-2584. Epub 2005 Aug 23. Blood. 2005. PMID: 16118318 Free article.

3

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.

Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J. Dong S, et al. Among authors: lonial s. Blood. 2007 Jul 1;110(1):360-9. doi: 10.1182/blood-2006-12-065615. Epub 2007 Mar 27. Blood. 2007. PMID: 17389761 Free PMC article.

4

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. Qiu Y, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4973-80. doi: 10.1158/0008-5472.CAN-06-4044. Cancer Res. 2007. PMID: 17510428

5

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. Liu X, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4981-8. doi: 10.1158/0008-5472.CAN-06-4274. Cancer Res. 2007. PMID: 17510429

6

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY. Elrod HA, et al. Among authors: lonial s. Mol Cancer Ther. 2007 Jul;6(7):2029-38. doi: 10.1158/1535-7163.MCT-07-0004. Epub 2007 Jun 29. Mol Cancer Ther. 2007. PMID: 17604333

7

Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.

Fu L, Kim YA, Wang X, Wu X, Yue P, Lonial S, Khuri FR, Sun SY. Fu L, et al. Among authors: lonial s. Cancer Res. 2009 Dec 1;69(23):8967-76. doi: 10.1158/0008-5472.CAN-09-2190. Epub 2009 Nov 17. Cancer Res. 2009. PMID: 19920197 Free PMC article.

8

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J. Hitosugi T, et al. Among authors: lonial s. Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431. Sci Signal. 2009. PMID: 19920251 Free PMC article.

9

Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IkappaB(alpha) degradation.

Li C, Chen S, Yue P, Deng X, Lonial S, Khuri FR, Sun SY. Li C, et al. Among authors: lonial s. J Biol Chem. 2010 May 21;285(21):16096-104. doi: 10.1074/jbc.M109.072694. Epub 2010 Mar 24. J Biol Chem. 2010. PMID: 20335171 Free PMC article.

10

The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells.

Zhao L, Yue P, Lonial S, Khuri FR, Sun SY. Zhao L, et al. Among authors: lonial s. Mol Cancer Ther. 2011 Dec;10(12):2415-25. doi: 10.1158/1535-7163.MCT-11-0401. Epub 2011 Sep 13. Mol Cancer Ther. 2011. PMID: 21914854 Free PMC article.

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