Longo FM - Search Results

1

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. Villeda SA, et al. Among authors: longo fm. Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4. Nat Med. 2014. PMID: 24793238 Free PMC article.

2

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. Czirr E, et al. Among authors: longo fm. J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15. J Exp Med. 2017. PMID: 28298456 Free PMC article.

3

Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.

Simmons DA, Longo FM, Massa SM. Simmons DA, et al. Among authors: longo fm. CNS Neurol Disord Drug Targets. 2017;16(3):291-302. doi: 10.2174/1871527315666161107093047. CNS Neurol Disord Drug Targets. 2017. PMID: 27823570 Review.

4

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Knowles JK, et al. Among authors: longo fm. Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29. Neurobiol Aging. 2013. PMID: 23545424 Free PMC article.

5

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM. Simmons DA, et al. Among authors: longo fm. J Neurosci. 2013 Nov 27;33(48):18712-27. doi: 10.1523/JNEUROSCI.1310-13.2013. J Neurosci. 2013. PMID: 24285878 Free PMC article.

6

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM. Yang T, et al. Among authors: longo fm. Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi: 10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19. Neuropharmacology. 2016. PMID: 27334657 Free article.

7

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM. Nguyen TV, et al. Among authors: longo fm. J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036. J Alzheimers Dis. 2014. PMID: 24898660 Free PMC article.

8

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. Simmons DA, et al. Among authors: longo fm. PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014. PLoS One. 2014. PMID: 25153701 Free PMC article.

9

TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.

Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM. Simmons DA, et al. Among authors: longo fm. Hum Mol Genet. 2018 Aug 15;27(16):2893-2912. doi: 10.1093/hmg/ddy202. Hum Mol Genet. 2018. PMID: 29860333 Free PMC article.

10

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. Knowles JK, et al. Among authors: longo fm. J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009. J Neurosci. 2009. PMID: 19710315 Free PMC article.

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