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Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months.
Santopaolo M, Gregorova M, Hamilton F, Arnold D, Long A, Lacey A, Oliver E, Halliday A, Baum H, Hamilton K, Milligan R, Pearce O, Knezevic L, Morales Aza B, Milne A, Milodowski E, Jones E, Lazarus R, Goenka A, Finn A, Maskell N, Davidson AD, Gillespie K, Wooldridge L, Rivino L. Santopaolo M, et al. Among authors: long a. Elife. 2023 Jun 13;12:e85009. doi: 10.7554/eLife.85009. Elife. 2023. PMID: 37310006 Free PMC article.
Coronavirus disease-19 (COVID-19) causes immune perturbations which may persist long term, and patients frequently report ongoing symptoms for months after recovery. ...Our data suggests that long COVID and persistent immune activation may correlate independently wi …
Coronavirus disease-19 (COVID-19) causes immune perturbations which may persist long term, and patients frequently report ongoing sym …
Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes.
Ye J, Long AE, Pearson JA, Taylor H, Bingley PJ, Williams AJ, Gillespie KM. Ye J, et al. Among authors: long ae. Diabetologia. 2015 Oct;58(10):2284-7. doi: 10.1007/s00125-015-3702-9. Epub 2015 Jul 30. Diabetologia. 2015. PMID: 26224099
AIMS/HYPOTHESIS: The rate of progression from islet autoimmunity to clinical type 1 diabetes depends on the rate of beta cell destruction. The HLA-A*24 gene is associated with early diabetes onset, but previous studies have shown attenuated humoral responses to islet antig …
AIMS/HYPOTHESIS: The rate of progression from islet autoimmunity to clinical type 1 diabetes depends on the rate of beta cell destruction. T …
Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes.
Williams GM, Long AE, Wilson IV, Aitken RJ, Wyatt RC, McDonald TJ, Wong FS, Hattersley AT, Williams AJ, Bingley PJ, Gillespie KM. Williams GM, et al. Diabetologia. 2016 Dec;59(12):2722-2726. doi: 10.1007/s00125-016-4087-0. Epub 2016 Sep 3. Diabetologia. 2016. PMID: 27591853 Free PMC article.
AIMS/HYPOTHESIS: This study aimed to determine the frequency of residual beta cell function in individuals with long-standing type 1 diabetes who were recruited at diagnosis, and relate this to baseline and current islet autoantibody profile. METHODS: Two hour post-meal ur …
AIMS/HYPOTHESIS: This study aimed to determine the frequency of residual beta cell function in individuals with long-standing type 1 …
Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype.
Hanna SJ, Powell WE, Long AE, Robinson EJS, Davies J, Megson C, Howell A, Jones TJ, Ladell K, Price DA, Dayan CM, Williams AJK, Gillespie KM, Wong FS. Hanna SJ, et al. Among authors: long ae. Diabetologia. 2020 Jun;63(6):1174-1185. doi: 10.1007/s00125-020-05114-7. Epub 2020 Mar 10. Diabetologia. 2020. PMID: 32157332 Free PMC article.
METHODS: Immunological variables were compared across peripheral blood samples obtained from slow progressors to type 1 diabetes, individuals with newly diagnosed or long-standing type 1 diabetes, and healthy individuals. Polychromatic flow cytometry was used to characteri …
METHODS: Immunological variables were compared across peripheral blood samples obtained from slow progressors to type 1 diabetes, individual …
Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2.
Goenka A, Halliday A, Gregorova M, Milodowski E, Thomas A, Williamson MK, Baum H, Oliver E, Long AE, Knezevic L, Williams AJK, Lampasona V, Piemonti L, Gupta K, Di Bartolo N, Berger I, Toye AM, Vipond B, Muir P, Bernatoniene J, Bailey M, Gillespie KM, Davidson AD, Wooldridge L, Rivino L, Finn A. Goenka A, et al. Among authors: long ae. Cell Rep Med. 2021 Jul 20;2(7):100327. doi: 10.1016/j.xcrm.2021.100327. Epub 2021 Jun 9. Cell Rep Med. 2021. PMID: 34124701 Free PMC article.
1,856 results