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Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
Gehrtz P, Marom S, Bührmann M, Hardick J, Kleinbölting S, Shraga A, Dubiella C, Gabizon R, Wiese JN, Müller MP, Cohen G, Babaev I, Shurrush K, Avram L, Resnick E, Barr H, Rauh D, London N. Gehrtz P, et al. Among authors: london n. J Med Chem. 2022 Aug 11;65(15):10341-10356. doi: 10.1021/acs.jmedchem.1c02206. Epub 2022 Jul 30. J Med Chem. 2022. PMID: 35912476 Free PMC article.
Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.
Shraga A, Olshvang E, Davidzohn N, Khoshkenar P, Germain N, Shurrush K, Carvalho S, Avram L, Albeck S, Unger T, Lefker B, Subramanyam C, Hudkins RL, Mitchell A, Shulman Z, Kinoshita T, London N. Shraga A, et al. Among authors: london n. Cell Chem Biol. 2019 Jan 17;26(1):98-108.e5. doi: 10.1016/j.chembiol.2018.10.011. Epub 2018 Nov 15. Cell Chem Biol. 2019. PMID: 30449673 Free article.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N. Resnick E, et al. Among authors: london n. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22. J Am Chem Soc. 2019. PMID: 31060360 Free PMC article.
Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs.
Gabizon R, Shraga A, Gehrtz P, Livnah E, Shorer Y, Gurwicz N, Avram L, Unger T, Aharoni H, Albeck S, Brandis A, Shulman Z, Katz BZ, Herishanu Y, London N. Gabizon R, et al. Among authors: london n. J Am Chem Soc. 2020 Jul 8;142(27):11734-11742. doi: 10.1021/jacs.9b13907. Epub 2020 May 19. J Am Chem Soc. 2020. PMID: 32369353 Free PMC article.
A Fast and Clean BTK Inhibitor.
Gabizon R, London N. Gabizon R, et al. Among authors: london n. J Med Chem. 2020 May 28;63(10):5100-5101. doi: 10.1021/acs.jmedchem.0c00597. Epub 2020 May 13. J Med Chem. 2020. PMID: 32401033 Free PMC article. Review.
Correction to Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs.
Gabizon R, Shraga A, Gehrtz P, Livnah E, Shorer Y, Gurwicz N, Avram L, Unger T, Aharoni H, Albeck S, Brandis A, Shulman Z, Katz BZ, Herishanu Y, London N. Gabizon R, et al. Among authors: london n. J Am Chem Soc. 2020 Jun 24;142(25):11316. doi: 10.1021/jacs.0c05753. Epub 2020 Jun 10. J Am Chem Soc. 2020. PMID: 32520539 Free PMC article. No abstract available.
Hitting KRAS When It's Down.
Gabizon R, London N. Gabizon R, et al. Among authors: london n. J Med Chem. 2020 Jul 9;63(13):6677-6678. doi: 10.1021/acs.jmedchem.0c00785. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32568546 Free PMC article.
Structural basis for producing selective MAP2K7 inhibitors.
Murakawa Y, Valter S, Barr H, London N, Kinoshita T. Murakawa Y, et al. Among authors: london n. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127546. doi: 10.1016/j.bmcl.2020.127546. Epub 2020 Sep 12. Bioorg Med Chem Lett. 2020. PMID: 32931911
658 results