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A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
Roberts KD, Zhu Y, Azad MAK, Han ML, Wang J, Wang L, Yu HH, Horne AS, Pinson JA, Rudd D, Voelcker NH, Patil NA, Zhao J, Jiang X, Lu J, Chen K, Lomovskaya O, Hecker SJ, Thompson PE, Nation RL, Dudley MN, Griffith DC, Velkov T, Li J. Roberts KD, et al. Among authors: lomovskaya o. Nat Commun. 2022 Mar 25;13(1):1625. doi: 10.1038/s41467-022-29234-3. Nat Commun. 2022. PMID: 35338128 Free PMC article.
Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Lomovskaya O, Nelson K, Rubio-Aparicio D, Tsivkovski R, Sun D, Dudley MN. Lomovskaya O, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e00552-20. doi: 10.1128/AAC.00552-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32229498 Free PMC article.
In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms.
Nelson K, Rubio-Aparicio D, Sun D, Dudley M, Lomovskaya O. Nelson K, et al. Among authors: lomovskaya o. Antimicrob Agents Chemother. 2020 Jul 22;64(8):e00757-20. doi: 10.1128/AAC.00757-20. Print 2020 Jul 22. Antimicrob Agents Chemother. 2020. PMID: 32482673 Free PMC article.
In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii.
Nelson K, Rubio-Aparicio D, Tsivkovski R, Sun D, Totrov M, Dudley M, Lomovskaya O. Nelson K, et al. Among authors: lomovskaya o. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01406-20. doi: 10.1128/AAC.01406-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32868334 Free PMC article.
In Vitro Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa.
Lomovskaya O, Rubio-Aparicio D, Nelson K, Sun D, Tsivkovski R, Castanheira M, Lindley J, Loutit J, Dudley M. Lomovskaya O, et al. Antimicrob Agents Chemother. 2021 May 18;65(6):e00210-21. doi: 10.1128/AAC.00210-21. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33782010 Free PMC article.
In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales.
Lomovskaya O, Castanheira M, Lindley J, Rubio-Aparicio D, Nelson K, Tsivkovski R, Sun D, Totrov M, Loutit J, Dudley M. Lomovskaya O, et al. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0044023. doi: 10.1128/aac.00440-23. Epub 2023 Oct 6. Antimicrob Agents Chemother. 2023. PMID: 37800963 Free PMC article.
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