Lombardi S - Search Results

1

5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2).

Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. Bursavich MG, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5630-3. doi: 10.1016/j.bmcl.2007.07.048. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17804234

2

Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2).

Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. Bursavich MG, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1185-8. doi: 10.1016/j.bmcl.2006.12.027. Epub 2006 Dec 12. Bioorg Med Chem Lett. 2007. PMID: 17210251

3

5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5.

Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. Gilbert AM, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92. doi: 10.1016/j.bmcl.2006.12.020. Epub 2006 Dec 12. Bioorg Med Chem Lett. 2007. PMID: 17210252

4

N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).

Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. Gilbert AM, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6454-7. doi: 10.1016/j.bmcl.2008.10.065. Epub 2008 Oct 18. Bioorg Med Chem Lett. 2008. PMID: 18974001

5

Hit to lead studies on (hetero)arylpyrimidines--agonists of the canonical Wnt-beta-catenin cellular messaging system.

Gilbert AM, Bursavich MG, Alon N, Bhat BM, Bex FJ, Cain M, Coleburn V, Gironda V, Green P, Hauze DB, Kharode Y, Krishnamurthy G, Kirisits M, Lam HS, Liu YB, Lombardi S, Matteo J, Murrills R, Robinson JA, Selim S, Sharp M, Unwalla R, Varadarajan U, Zhao W, Yaworsky PJ. Gilbert AM, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2010 Jan 1;20(1):366-70. doi: 10.1016/j.bmcl.2009.10.093. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2010. PMID: 19897365

6

Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.

Gilbert AM, Nowak P, Brooijmans N, Bursavich MG, Dehnhardt C, Santos ED, Feldberg LR, Hollander I, Kim S, Lombardi S, Park K, Venkatesan AM, Mallon R. Gilbert AM, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. doi: 10.1016/j.bmcl.2009.11.051. Epub 2009 Dec 5. Bioorg Med Chem Lett. 2010. PMID: 19969455

7

Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.

Bursavich MG, Brooijmans N, Feldberg L, Hollander I, Kim S, Lombardi S, Park K, Mallon R, Gilbert AM. Bursavich MG, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2586-90. doi: 10.1016/j.bmcl.2010.02.082. Epub 2010 Feb 23. Bioorg Med Chem Lett. 2010. PMID: 20303263

8

Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines.

Bursavich MG, Lombardi S, Gilbert AM. Bursavich MG, et al. Among authors: lombardi s. Org Lett. 2005 Sep 15;7(19):4113-6. doi: 10.1021/ol051339z. Org Lett. 2005. PMID: 16146365

9

3-(Pyridin-2-yl-ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: hit to lead studies.

Gilbert AM, Bursavich MG, Lombardi S, Adedoyin A, Dwyer JM, Hughes Z, Kern JC, Khawaja X, Rosenzweig-Lipson S, Moore WJ, Neal SJ, Olsen M, Rizzo SJ, Springer D. Gilbert AM, et al. Among authors: lombardi s. Bioorg Med Chem Lett. 2011 Jan 1;21(1):195-9. doi: 10.1016/j.bmcl.2010.11.038. Epub 2010 Nov 12. Bioorg Med Chem Lett. 2011. PMID: 21126874

10

Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.

Cole DC, Lennox WJ, Lombardi S, Ellingboe JW, Bernotas RC, Tawa GJ, Mazandarani H, Smith DL, Zhang G, Coupet J, Schechter LE. Cole DC, et al. Among authors: lombardi s. J Med Chem. 2005 Jan 27;48(2):353-6. doi: 10.1021/jm049243i. J Med Chem. 2005. PMID: 15658848

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