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New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
Pippione AC, Kilic-Kurt Z, Kovachka S, Sainas S, Rolando B, Denasio E, Pors K, Adinolfi S, Zonari D, Bagnati R, Lolli ML, Spyrakis F, Oliaro-Bosso S, Boschi D. Pippione AC, et al. Among authors: lolli ml. Eur J Med Chem. 2022 Jul 5;237:114366. doi: 10.1016/j.ejmech.2022.114366. Epub 2022 Apr 13. Eur J Med Chem. 2022. PMID: 35447434 Free article.
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
Lolli ML, Giordano C, Pickering DS, Rolando B, Hansen KB, Foti A, Contreras-Sanz A, Amir A, Fruttero R, Gasco A, Nielsen B, Johansen TN. Lolli ML, et al. J Med Chem. 2010 May 27;53(10):4110-8. doi: 10.1021/jm1001452. J Med Chem. 2010. PMID: 20408529 Free article.
1,2,5-Oxadiazole analogues of leflunomide and related compounds.
Giorgis M, Lolli ML, Rolando B, Rao A, Tosco P, Chaurasia S, Marabello D, Fruttero R, Gasco A. Giorgis M, et al. Among authors: lolli ml. Eur J Med Chem. 2011 Jan;46(1):383-92. doi: 10.1016/j.ejmech.2010.10.029. Epub 2010 Nov 3. Eur J Med Chem. 2011. PMID: 21109332
63 results