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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Klein VG, et al. Among authors: lokey rs. ACS Med Chem Lett. 2020 Jul 30;11(9):1732-1738. doi: 10.1021/acsmedchemlett.0c00265. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32939229 Free PMC article.
Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.
Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Bockus AT, et al. Among authors: lokey rs. J Med Chem. 2015 Jun 11;58(11):4581-9. doi: 10.1021/acs.jmedchem.5b00128. Epub 2015 May 20. J Med Chem. 2015. PMID: 25950816
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein VG, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, Lokey RS. Naylor MR, et al. Among authors: lokey rs. J Med Chem. 2018 Dec 27;61(24):11169-11182. doi: 10.1021/acs.jmedchem.8b01259. Epub 2018 Dec 11. J Med Chem. 2018. PMID: 30395703
Conformation and Permeability: Cyclic Hexapeptide Diastereomers.
Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lokey RS. Ono S, et al. Among authors: lokey rs. J Chem Inf Model. 2019 Jun 24;59(6):2952-2963. doi: 10.1021/acs.jcim.9b00217. Epub 2019 May 8. J Chem Inf Model. 2019. PMID: 31042375 Free PMC article.
77 results