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A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Sblano S, Cerchia C, Laghezza A, Piemontese L, Brunetti L, Leuci R, Gilardi F, Thomas A, Genovese M, Santi A, Tortorella P, Paoli P, Lavecchia A, Loiodice F. Sblano S, et al. Among authors: loiodice f. Eur J Med Chem. 2022 May 5;235:114240. doi: 10.1016/j.ejmech.2022.114240. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35325635
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.
Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Conte-Camerino D, De Luca A, Liantonio A. Carbonara G, et al. Among authors: loiodice f. Farmaco. 2001 Oct;56(10):749-54. doi: 10.1016/s0014-827x(01)01127-2. Farmaco. 2001. PMID: 11718267
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.
Liantonio A, De Luca A, Pierno S, Didonna MP, Loiodice F, Fracchiolla G, Tortorella P, Antonio L, Bonerba E, Traverso S, Elia L, Picollo A, Pusch M, Camerino DC. Liantonio A, et al. Among authors: loiodice f. Br J Pharmacol. 2003 Aug;139(7):1255-64. doi: 10.1038/sj.bjp.0705364. Br J Pharmacol. 2003. PMID: 12890704 Free PMC article.
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers.
Liantonio A, Pusch M, Picollo A, Guida P, De Luca A, Pierno S, Fracchiolla G, Loiodice F, Tortorella P, Conte Camerino D. Liantonio A, et al. Among authors: loiodice f. J Am Soc Nephrol. 2004 Jan;15(1):13-20. doi: 10.1097/01.asn.0000103226.28798.ea. J Am Soc Nephrol. 2004. PMID: 14694153
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study.
Lavecchia A, Cosconati S, Novellino E, Calleri E, Temporini C, Massolini G, Carbonara G, Fracchiolla G, Loiodice F. Lavecchia A, et al. Among authors: loiodice f. J Mol Graph Model. 2007 Mar;25(6):773-83. doi: 10.1016/j.jmgm.2006.07.001. Epub 2006 Aug 8. J Mol Graph Model. 2007. PMID: 16901739
103 results