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Page 1
Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder.
Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, Hodgkinson CA, Vendruscolo LF, Koob GF, Schwandt M, George DT, Jones IS, Holmes A, Zhou Z, Xu MJ, Gao B, Sun H, Phillips MJ, Muench C, Kaminsky ZA. Lohoff FW, et al. Mol Psychiatry. 2018 Sep;23(9):1900-1910. doi: 10.1038/mp.2017.168. Epub 2017 Aug 29. Mol Psychiatry. 2018. PMID: 28848234 Free PMC article.
Genetic Association and Expression Analyses of the Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) Gene in Alcohol Use Disorder-Relevance for Pain Signaling and Alcohol Use.
Lee JS, Sorcher JL, Rosen AD, Damadzic R, Sun H, Schwandt M, Heilig M, Kelly J, Mauro KL, Luo A, Rosoff D, Muench C, Jung J, Kaminsky ZA, Lohoff FW. Lee JS, et al. Among authors: lohoff fw. Alcohol Clin Exp Res. 2018 Jun;42(6):1034-1043. doi: 10.1111/acer.13751. Epub 2018 May 9. Alcohol Clin Exp Res. 2018. PMID: 29667742 Free PMC article.
PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease.
Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW. Lee JS, et al. Among authors: lohoff fw. Sci Rep. 2019 Nov 20;9(1):17167. doi: 10.1038/s41598-019-53603-6. Sci Rep. 2019. PMID: 31748600 Free PMC article.
Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation.
Lohoff FW, Roy A, Jung J, Longley M, Rosoff DB, Luo A, O'Connell E, Sorcher JL, Sun H, Schwandt M, Hodgkinson CA, Goldman D, Momenan R, McIntosh AM, Adams MJ, Walker RM, Evans KL, Porteous D, Smith AK, Lee J, Muench C, Charlet K, Clarke TK, Kaminsky ZA. Lohoff FW, et al. Mol Psychiatry. 2021 Jun;26(6):2224-2237. doi: 10.1038/s41380-020-0734-4. Epub 2020 May 12. Mol Psychiatry. 2021. PMID: 32398718 Free PMC article.
Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target.
Lohoff FW, Clarke TK, Kaminsky ZA, Walker RM, Bermingham ML, Jung J, Morris SW, Rosoff D, Campbell A, Barbu M, Charlet K, Adams M, Lee J, Howard DM, O'Connell EM, Whalley H, Porteous DJ, McIntosh AM, Evans KL. Lohoff FW, et al. Mol Psychiatry. 2022 Mar;27(3):1754-1764. doi: 10.1038/s41380-021-01378-6. Epub 2021 Dec 2. Mol Psychiatry. 2022. PMID: 34857913 Free PMC article.
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study.
Rosoff DB, Bell AS, Mavromatis LA, Hamandi A, Park L, Jung J, Wagner J, Pacher P, Ray D, Davey Smith G, Lohoff FW. Rosoff DB, et al. Among authors: lohoff fw. Circ Genom Precis Med. 2024 Feb;17(1):e004224. doi: 10.1161/CIRCGEN.122.004224. Epub 2024 Jan 23. Circ Genom Precis Med. 2024. PMID: 38258565 No abstract available.
Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder.
Zillich L, Cetin M, Hummel EM, Poisel E, Fries GR, Frank J, Streit F, Foo JC, Sirignano L, Friske MM, Lenz B, Hoffmann S, Adorjan K, Kiefer F, Bakalkin G, Hansson AC, Lohoff FW, Kärkkäinen O, Kok E, Karhunen PJ, Sutherland GT, Walss-Bass C, Spanagel R, Rietschel M, Moser DA, Witt SH. Zillich L, et al. Among authors: lohoff fw. Alcohol Clin Exp Res (Hoboken). 2024 Feb;48(2):250-259. doi: 10.1111/acer.15241. Epub 2024 Jan 26. Alcohol Clin Exp Res (Hoboken). 2024. PMID: 38276909
154 results