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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: loh k. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
Reactive oxygen species enhance insulin sensitivity.
Loh K, Deng H, Fukushima A, Cai X, Boivin B, Galic S, Bruce C, Shields BJ, Skiba B, Ooms LM, Stepto N, Wu B, Mitchell CA, Tonks NK, Watt MJ, Febbraio MA, Crack PJ, Andrikopoulos S, Tiganis T. Loh K, et al. Cell Metab. 2009 Oct;10(4):260-72. doi: 10.1016/j.cmet.2009.08.009. Cell Metab. 2009. PMID: 19808019 Free PMC article.
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Loh K, et al. Cell Metab. 2011 Nov 2;14(5):684-99. doi: 10.1016/j.cmet.2011.09.011. Epub 2011 Oct 13. Cell Metab. 2011. PMID: 22000926 Free PMC article.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Dodd GT, et al. Among authors: loh k. Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022. Cell. 2015. PMID: 25594176 Free PMC article.
1,171 results