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Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. Fribourg M, et al. Among authors: logothetis de. Cell. 2011 Nov 23;147(5):1011-23. doi: 10.1016/j.cell.2011.09.055. Cell. 2011. PMID: 22118459 Free PMC article.
G protein-coupled receptor signaling to Kir channels in Xenopus oocytes.
Hatcher-Solis C, Fribourg M, Spyridaki K, Younkin J, Ellaithy A, Xiang G, Liapakis G, Gonzalez-Maeso J, Zhang H, Cui M, Logothetis DE. Hatcher-Solis C, et al. Among authors: logothetis de. Curr Pharm Biotechnol. 2014;15(10):987-95. doi: 10.2174/1389201015666141031111916. Curr Pharm Biotechnol. 2014. PMID: 25374032 Free PMC article. Review.
Mechanism of PLC-mediated Kir3 current inhibition.
Keselman I, Fribourg M, Felsenfeld DP, Logothetis DE. Keselman I, et al. Among authors: logothetis de. Channels (Austin). 2007 Mar-Apr;1(2):113-23. doi: 10.4161/chan.4321. Epub 2007 Apr 23. Channels (Austin). 2007. PMID: 18690019
G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs).
Ferré S, Ciruela F, Dessauer CW, González-Maeso J, Hébert TE, Jockers R, Logothetis DE, Pardo L. Ferré S, et al. Among authors: logothetis de. Pharmacol Ther. 2022 Mar;231:107977. doi: 10.1016/j.pharmthera.2021.107977. Epub 2021 Sep 1. Pharmacol Ther. 2022. PMID: 34480967 Free PMC article. Review.
Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists.
Younkin J, Gaitonde SA, Ellaithy A, Vekariya R, Baki L, Moreno JL, Shah S, Drossopoulos P, Hideshima KS, Eltit JM, González-Maeso J, Logothetis DE, Dukat M, Glennon RA. Younkin J, et al. Among authors: logothetis de. ACS Chem Neurosci. 2016 Sep 21;7(9):1292-9. doi: 10.1021/acschemneuro.6b00162. Epub 2016 Jul 19. ACS Chem Neurosci. 2016. PMID: 27385190 Free PMC article.
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. Moreno JL, et al. Among authors: logothetis de. Sci Signal. 2016 Jan 12;9(410):ra5. doi: 10.1126/scisignal.aab0467. Sci Signal. 2016. PMID: 26758213 Free PMC article.
143 results