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Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.
Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Sinha M, et al. Among authors: loffredo fs. Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5. Science. 2014. PMID: 24797481 Free PMC article.
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy.
Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Loffredo FS, et al. Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015. Cell. 2013. PMID: 23663781 Free PMC article.
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age.
Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Poggioli T, et al. Among authors: loffredo fs. Circ Res. 2016 Jan 8;118(1):29-37. doi: 10.1161/CIRCRESAHA.115.307521. Epub 2015 Oct 21. Circ Res. 2016. PMID: 26489925 Free PMC article.
Keep PNUTS in your heart.
Loffredo FS, Pancoast JR, Lee RT. Loffredo FS, et al. Circ Res. 2013 Jul 5;113(2):97-9. doi: 10.1161/CIRCRESAHA.113.301933. Circ Res. 2013. PMID: 23833289
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.
Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Walker RG, et al. Among authors: loffredo fs. Sci Rep. 2020 Mar 12;10(1):4561. doi: 10.1038/s41598-020-61443-y. Sci Rep. 2020. PMID: 32165710 Free PMC article.
Therapeutic vasculogenesis: it takes two.
Loffredo F, Lee RT. Loffredo F, et al. Circ Res. 2008 Jul 18;103(2):128-30. doi: 10.1161/CIRCRESAHA.108.180604. Circ Res. 2008. PMID: 18635829 Free PMC article. No abstract available.
36 results