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EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Morel KL, Sheahan AV, Burkhart DL, Baca SC, Boufaied N, Liu Y, Qiu X, Cañadas I, Roehle K, Heckler M, Calagua C, Ye H, Pantelidou C, Galbo P, Panja S, Mitrofanova A, Wilkinson S, Whitlock NC, Trostel SY, Hamid AA, Kibel AS, Barbie DA, Choudhury AD, Pomerantz MM, Sweeney CJ, Long HW, Einstein DJ, Shapiro GI, Dougan SK, Sowalsky AG, He HH, Freedman ML, Balk SP, Loda M, Labbé DP, Olson BM, Ellis L. Morel KL, et al. Among authors: loda m. Nat Cancer. 2021 Apr;2(4):444-456. doi: 10.1038/s43018-021-00185-w. Epub 2021 Mar 22. Nat Cancer. 2021. PMID: 33899001 Free PMC article.
Gene expression correlates of clinical prostate cancer behavior.
Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D'Amico AV, Richie JP, Lander ES, Loda M, Kantoff PW, Golub TR, Sellers WR. Singh D, et al. Among authors: loda m. Cancer Cell. 2002 Mar;1(2):203-9. doi: 10.1016/s1535-6108(02)00030-2. Cancer Cell. 2002. PMID: 12086878 Free article.
A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell cycle inhibitor.
Haddad RI, Weinstein LJ, Wieczorek TJ, Bhattacharya N, Raftopoulos H, Oster MW, Zhang X, Latham VM Jr, Costello R, Faucher J, DeRosa C, Yule M, Miller LP, Loda M, Posner MR, Shapiro GI. Haddad RI, et al. Among authors: loda m. Clin Cancer Res. 2004 Jul 15;10(14):4680-7. doi: 10.1158/1078-0432.CCR-04-0229. Clin Cancer Res. 2004. PMID: 15269140 Clinical Trial.
Androgen-dependent regulation of Her-2/neu in prostate cancer cells.
Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M. Berger R, et al. Among authors: loda m. Cancer Res. 2006 Jun 1;66(11):5723-8. doi: 10.1158/0008-5472.CAN-05-3928. Cancer Res. 2006. PMID: 16740710
The isopeptidase USP2a protects human prostate cancer from apoptosis.
Priolo C, Tang D, Brahamandan M, Benassi B, Sicinska E, Ogino S, Farsetti A, Porrello A, Finn S, Zimmermann J, Febbo P, Loda M. Priolo C, et al. Among authors: loda m. Cancer Res. 2006 Sep 1;66(17):8625-32. doi: 10.1158/0008-5472.CAN-06-1374. Cancer Res. 2006. PMID: 16951176
494 results